objective: dendrimers are three-dimensional nanostructures that have numerous applications in medicine, including drug delivery and imaging. although anionic dendrimer polyethylene glycol–citrate has a high potential to increase solubility of water-insoluble drugs and drug delivery, its multi-step synthesis procedure is time consuming. in addition, toxic substances such as dichloromethane are u...

Multi-step forecasts can be produced recursively by iterating a one-step model, or directly using a specific model for each horizon. Choosing between these two strategies is not an easy task since it involves a trade-off between bias and estimation variance over the forecast horizon. Using a nonlinear machine learning model makes the tradeoff even more difficult. To address this issue, we propo...

While natural language as an interaction modality is increasingly being accepted by users, remaining technological challenges still hinder its widespread employment. Tools that better support the design, development and improvement of these types of applications are required. This demo presents a prototyping framework for Spoken Dialog System (SDS) design which combines existing language techno...

Multi-step forecasts can be produced recursively by iterating a one-step model, or directly using a specific model for each horizon. Choosing between these two strategies is not an easy task since it involves a trade-off between bias and estimation variance over the forecast horizon. Using a nonlinear machine learning model makes the tradeoff even more difficult. To address this issue, we propo...

In this work, we have developed a fourth order Newton-like method based on harmonic mean and its multi-step version for solving system of nonlinear equations. The new fourth order method requires evaluation of one function and two first order Fréchet derivatives for each iteration. The multi-step version requires one more function evaluation for each iteration. The proposed new scheme does not ...

The Interaction Picture (IP) method is a valuable alternative to Split-step methods for solving certain types of partial differential equations such as the nonlinear Schrödinger equation or the Gross-Pitaevskii equation. Although very similar to the Symmetric Split-step (SS) method in its inner computational structure, the IP method results from a change of unknown and therefore do not involve ...