In 1998 John Pople and Walter Kohn shared the Nobel Prize in Chemistry for the development of wave-function theory (WFT) and density-functional theory (DFT) methods, respectively. In 2013 the Chemistry Nobel Prize was awarded to Martin Karplus, Michael Levitt, and Arieh Warshel for the development of multi-scale methods. These electronic structure methods cover a wide range of accuracy and appl...

Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With...

This study aimed to evaluate the effect of supplementing different protease enzymes on growth performance, intestinal morphology, and selected carcass traits in broilers fed diets reduced 3.5% crude protein (CP) amino acids (AA). One thousand one-day-old Ross 308 (41 g) were assigned five dietary treatments with ten replicates 20 birds each: (PC) a positive control diet formulated meet acid req...

Dualor multi-target ligands have gained increased attention in the past years due to several advantages, including more simple pharmacokinetic and phamarcodynamic properties compared to a combined application of several drugs. Furthermore multi-target ligands often possess improved efficacy [1]. We present a new approach for the discovery of dual-target ligands using aligned pharmacophore model...

an experiment was conducted to evaluate the effects of supplementing black cumin (nigella sativa) seeds (bcs) in diet on performance, liver weight and enzymes of broilers.the experiment was conducted as a randomized complete block design. two hundred forty day-old unsexed broiler chicks (cobb 500) were divided into four groups and assigned to four feeding treatments, with four replicates of 15 ...

this study was aimed to evaluate the effect of gnrh injection on semen ejaculate characteristics in awassi rams collected in breeding and non breeding seasons. the study was conducted in late summer to early autumn when breeding activity commences, and in winter during the non breeding season. twelve mature awassi rams were used in this study. animals were randomly allocated into two equal grou...

background and aims: artichoke (cynara scolymus l.) is a plant of the asteraceae family. this plant is used in herbal medicine. this study was conducted to evaluate the effect of artichokeextract on insulin, glucagon, glucose, alkaline phosphatase (alp), alanine amino transferase (alt) and aspartate amino transferase (ast) in streptozotocin-induced diabetic rats. methods: in this experimental s...

background: the aim of this study was to evaluate the possible protective effect of sodium selenite on serum, liver, and kidney antioxidant enzymes activities in alloxan-induced type 1 diabetic rats. methods: forty sprague-dawley male rats were randomly divided into four groups; group one as control, group two as sham-treated with sodium selenite by 1 mg/kg intraperitoneal (i.p.) injections dai...

background :  pathogenic bacteria because of beta-lactam antibiotic resistance genes are dangerous to society. this resistance due to esbl genes, plasmids and transposons that by receiving or mutation occurs. the most important factor beta-lactam antibiotic resistance is beta lactamase enzymes. the purpose of this study was to evaluate the frequency of hospital opportunistic pathogenic bacteria...

conclusions these results indicate the lipid-lowering effects of quince leaf similar to atorvastatin and it can probably serve as a new potential natural product for atherosclerosis treatment. results oral administration of cholesterol for 8 weeks resulted in a significant increase (p < 0.05) in plasma markers. treatment with the extract at dose of 50 mg/kg and 0.5 mg/kg of atorvastatin not onl...