Although mucins are essential for the protection of internal epithelial surfaces, molecular responses involving mucin production and secretion in response to various infectious agents in the airway have not been fully elucidated. The present study analysed airway goblet cell mucins in rats infected with the nematode Nippostrongylus brasiliensis, which migrates to the lungs shortly after infecti...

Intraductal papillary neoplasms of the bile duct (IPNB) shows favorable prognosis and is regarded as a biliary counterpart of intraductal papillary mucinous neoplasm (IPMN) of the pancreas. Although activating point mutations of GNAS at codon 201 have been detected in approximately two thirds of IPMNs of the pancreas, there have been few studies on GNAS mutations in IPNBs. This study investigat...

The polymeric mucin component of the intestinal mucus barrier changes during nematode infection to provide not only physical protection but also to directly affect pathogenic nematodes and aid expulsion. Despite this, the direct interaction of the nematodes with the mucins and the mucus barrier has not previously been addressed. We used the well-established Trichuris muris nematode model to inv...

Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting in altered maturation and increased migration of epithelial cells in the intestine. They were also more likely to develop intestinal, colon, and rectal tumors. The mice are the first good model for studying rectal tumors, which are common in humans. Anticancer lubrication new mouse model for the s...

Mice lacking Muc2 had an increased ratio of proliferating to apoptotic epithelial cells, resulting in altered maturation and increased migration of epithelial cells in the intestine. They were also more likely to develop intestinal, colon, and rectal tumors. The mice are the first good model for studying rectal tumors, which are common in humans. Anticancer lubrication new mouse model for the s...

The model of mucins as enormously large linear polymers with limited organization has dominated the mucus field. Twenty-five years ago, Verdugo et al. (1) suggested that the mucins are stored as such in the regulated secretory pathway of goblet cells and packed by calcium ions shielding the negative charges (sialic acid and sulfate groups) of the highly glycosylated mucin domains (1, 2). That C...

BACKGROUND We investigated the occurrence and clinical significance of mucin expression in ampullary adenocarcinoma. METHODS We retrospectively analyzed clinical, pathological, and survival data from 74 ampullary adenocarcinoma patients who received radical operation from January 2004 to November 2006. RESULTS The tumors were located in the lower end of the common bile duct (46%), papillary...

The spleen plays an important role in coordinating both adaptive and innate immune responses. Here, the transcriptional response to T. gondii infection in the murine spleen was characterized concerning inflammasome sensors (two different models: seven days after oral or four weeks after intraperitoneal infection). Additionally, Tff1KO and Tff3KO mice were investigated because TFF genes are ofte...

We previously reported the presence of MUC2, MUC5AC and, for the first time, MUC5B in a 58-year-old male with pseudomyxoma peritonei (PMP). This is a report on the biochemical and immunohistochemical characterization of mucin in a 50-year-old female with the same rare illness. A right oophorectomy and appendicectomy and a resection of the involved omentum were performed. Approximately a litre o...