Extending previous work on prediction of phoneme recognition error from unlabelled data, corrupted by unpredictable factors, the current work investigates a simple but effective method of estimating ASR performance by computing Mean Temporal Distance (MTD), which is the mean distance between speech feature vectors, determined as a function of temporal distance between the vectors. It is shown t...

BACKGROUND/AIM We evaluated whether sub-stratifying intermediate-risk (IR) prostate cancer using the Memorial Sloan Kettering Cancer (MSKCC) or Prostate Cancer Risk Stratification (ProCaRS) model predicts for adverse imaging or pathologic features. PATIENTS AND METHODS 56 consecutive IR patients who underwent multi-parametric MRI (mpMRI) and radical prostatectomy (RP) were studied. The differ...

In this paper, we propose the intelligent bus alarm using Nokia N95 smart phone. The goal of this project is to provide a passive application which monitors the status of particular bus routes and alerts the user when they should leave for the bus. First, we created data which contains each bus schedule from C-U MTD web and MTD booklet. Second, we allowed a user to input a specific bus station ...

Methylthiodeoxynivalenol (MTD), a novel derivative of the trichothecene mycotoxin deoxynivalenol (DON), was prepared by applying a reliable procedure for the formal Michael addition of methanethiol to the conjugated double bond of DON. Structure elucidation revealed the preferred formation of the hemiketal form of MTD by intramolecular cyclisation between C8 and C15. Computational investigation...

RNA interference (RNAi) is mediated by small interfering (si) RNAs that target and degrade mRNA in a sequence-specific manner. Cellular expression of siRNA can be achieved by the use of expression cassettes driven by RNA polymerase III (pol III) promoters. Here, we demonstrate that a modified tRNA(met)-derived (MTD) promoter effectively drives the cellular expression of HIV-1-specific siRNA. We...

Vms1 translocates to damaged mitochondria in response to stress, whereupon its binding partner, Cdc48, contributes to mitochondrial protein homeostasis. Mitochondrial targeting of Vms1 is mediated by its conserved mitochondrial targeting domain (MTD), which, in unstressed conditions, is inhibited by intramolecular binding to the Vms1 leucine-rich sequence (LRS). Here, we report a 2.7 Å crystal ...

The minimal topological difference (MTD) method is used to describe quantitative structure-activity relationships (QSAR) for the progesterone-receptor binding affinity including 59 progestational steroids. Multiple correlation coefficients of r = 0.962 and r = 0.955 are obtained by use of the MTD variable and a measure of hydrophobicity for the series of progesterone and ethisterone derivatives...

Moving Target Defense (MTD) has emerged as a game changer in the security landscape, as it can create asymmetric uncertainty favoring the defender. Despite the significant work done in this area and the many different techniques that have been proposed, MTD has not yet gained widespread adoption due to several limitations. Specifically, interactions between multiple techniques have not been stu...

The algorithm for two-player game-tree search has a notorious reputation as being a challenging algorithm for achieving reasonable parallel performance. MTD(f), a new variant, has become the sequential algorithm of choice for practitioners. Unfortunately, MTD(f) inherits most of the parallel obstacles of , as well as creating new performance hurdles. Transposition-table-driven scheduling (TDS) ...

A minimal topological difference (MTD) approach is made to describe quantitative structure-activity relationships (QSAR) for the Na+, K+-ATPase inhibitory activity of cardiotonic steroids. The calculations take into account 20 derivatives of digitoxigenin, digoxigenin, and gitoxigenin with small substituents at different sites of the steroid backbone. A multiple correlation coefficient of r = 0...