Simiao pill, a Chinese herbal formula containing four herbs, has been used in the treatment of gouty arthritis for many years. The aim of this study was to explore the effects of modified Simiao decoction (MSD) on IL-1 β and TNF α secretion in monocytic THP-1 cells with monosodium urate (MSU) crystals-induced inflammation. The MSU crystals-induced inflammation model in THP-1 cells was successfu...

In recent single-particle tracking (SPT) measurements on Listeria monocytogenes motility in cells [Kuo and McGrath (2000)], the actin-based stochastic dynamics of the bacterium movement has been analyzed statistically in terms of the mean-square displacement (MSD) of the trajectory. We present a stochastic analysis of a simplified polymerization Brownian ratchet (BR) model in which motions are ...

We propose a method for obtaining the intrinsic, long-time mean square displacement (MSD) of atoms and molecules in proteins from finite-time molecular dynamics (MD) simulations. Typical data from simulations are limited to times of 1 to 10 ns, and over this time period the calculated MSD continues to increase without a clear limiting value. The proposed method consists of fitting a model to MD...

Conflictos de interés: MP es investigador principal en estudios clínicos auspiciados por MSD, Sanofi-Aventis, AstraZeneca, Novartis Biosciences, Roche y Phenomix Corporation; miembro del Advisory Board de Sanofi-Aventis del Perú; conferenciante para Sanofi-Aventis del Perú, Novartis Biosciences y BristolMyers Squibb; ha recibido auspicio para asistir a eventos científicos por Sanofi-Aventis del...

Analyzing a complex matrix can be accomplished using multiple specific detectors, but a significant time savings is realized using GC/MSD. Using an available Retention Time Locked database with Deconvolution Reporting Software (DRS) adds a second “expert” opinion. GC/MSD with DRS provides the fastest methodology to the fewest number of false positives/negatives with the greatest confidence in t...

Statement of Interest: J.B. Morjaria has received honoraria for speaking and financial support to attend meetings from Chiesi, Pfizer, MSD, Boehringer Ingelheim and GSK. A.H. Morice has received honoraria for speaker meetings and financial support to attend meetings/advisory boards from Chiesi, Pfizer, MSD, Boehringer Ingelheim, Novartis, GSK, AstraZeneca, Proctor & Gamble Healthcare, Orion Res...

OBJECTIVES There is significant variation in cut-off values for mean gestational sac diameter (MSD) and embryo crown-rump length (CRL) used to define miscarriage, values suggested in the literature ranging from 13 to 25 mm for MSD and from 3 to 8 mm for CRL. We aimed to define the false-positive rate (FPR) for the diagnosis of miscarriage associated with different CRL and MSD measurements with ...

BACKGROUND Exposures to occupational hazards substantially increase workers' risk of developing musculoskeletal disorders (MSDs) and can exacerbate pre-existing disorders. The effects on MSD risk of the physical requirements of work performance are well recognised, but there is now ample evidence that work-related psychosocial hazards can also have substantial effects; further, some hazards may...

UNLABELLED ESSENTIALS: Many anti-glycoprotein (GP)Ibα antibodies induce platelet clearance in a dimer-dependent manner. Characterization of monoclonal antibodies that bind the mechanosensitive domain (MSD) of GPIbα. An anti-MSD antibody binds two copies of GPIbα in platelets but does not induce platelet clearance. The prevailing clustering model of GPIbα signaling is incorrect or needs revision...

Introduction Musculoskeletal disorders (MSD) have become significant problems for all health care workers especially dentists. This systematic review provides prevalence of MSD in dentists of Iran. Material and Methods In this study all published literatures about MSD in Iranian dentists were selected without any time limits or other restrictions. However, it was found that the studies about ...