High-grade epithelial ovarian cancer kills more women than any other gynecologic cancer and is rarely diagnosed at an early stage. We sought to identify tumor-associated antigens (TAA) as candidate diagnostic and/or immunotherapeutic targets by taking advantage of tumor autoantibody responses in individuals with ovarian cancer. Plasma-derived IgG from a pool of five patients with advanced ovari...

There is a growing need for better assessment of health risks associated with land-applied biosolids. This study investigated in-situ decay of seeded human adenovirus (HAdV), Salmonella enterica, Escherichia coli, and bacteriophage (MS2) in biosolids-amended soil under wheat cultivation. The biosolids seeded with microorganisms were placed in decay chambers which were then placed in the topsoil...

Bacteriophage removal by soil passage in two field studies was re-analyzed with the goal to investigate differences between one- and two-dimensional modeling approaches, differences between one- and two-site kinetic sorption models, and the role of heterogeneities in the soil properties. The first study involved removal of bacteriophages MS2 and PRDI by dune recharge, while the second study rep...

BACKGROUND To assess the impact of a change in preclerkship grading system from Honors/Pass/Fail (H/P/F) to Pass/Fail (P/F) on University of California, San Diego (UCSD) medical students' academic performance. METHODS Academic performance of students in the classes of 2011 and 2012 (constant-grading classes) were collected and compared with performance of students in the class of 2013 (gradin...

The influence of trans -to-NO ligand (X) on the thermal stability transient side-on coordinated nitrosyl linkage isomer (MS2) is investigated in a series -[RuNOPy 4 X](PF 6 ) 2 (X = F − (RuF), Cl (RuCl), Br (RuBr) and OH (RuOH)) compounds.

Water, sanitation and hygiene interventions are among the most significant health interventions addressing the worldwide burden of diarrheal disease and environmental enteropathy. Sanitizing human excreta and animal manure (HEAM) is a critical step in reducing the spread of disease and ensuring microbially safe reuse of waste materials. From the perspective of human excreta, it was recently est...

OBJECTIVES The aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men. METHODS We conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55-65 years) who underwent whole-body cold exposure (15 min exposure to...

Eukaryotic translation initiation commences at the initiation codon near the 5' end of mRNA by a 40S ribosomal subunit, and the recruitment of a 40S ribosome to an mRNA is facilitated by translation initiation factors interacting with the m(7)G cap and/or poly(A) tail. The 40S ribosome recruited to an mRNA is then transferred to the AUG initiation codon with the help of translation initiation f...

Background: In obesity, as excessive adipose tissue accumulates, an altered metabolic profile occurs along with a variety of adaptations/alterations in the cardiac structure and function even in the absence of co-morbidities. Objective: To compare pre prandial and post prandial heart rate variability between young healthy non obese and obese females aged 18-25 years. Methods: 50 obese and 50 no...