Bone metastasis is a lethal and incurable disease. It is the result of the dissemination of cancer cells to the bone marrow. Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. Because mouse models represent a crucial tool with which to study cancer metast...

O NE OF the primary nlanifestations of tile clinical entity tropical sprue is a severe megaloblastic anemia. Although detailed descriptive information is available on tile blood and bone marrow morphology of this anenlia, its pathogenesis remains obscure.4’ The purpose of this report is to describe the quantitative aspects of red! cell production and dlestruction in this anemia. Our observation...

The antigenotoxic effect of ferulic acid was carried out by evaluating the cytogenetic markers, the micronuclei frequency and chromosomal aberrations, in the bone marrow of hamsters in 7,12-dimethylbenz(a)anthracene (DMBA) induced genotoxicity. Genotoxicity was induced in experimental hamsters by single intraperitoneal injection of DMBA (30 mg kg(-1) b.w.). Pretreatment of ferulic acid orally a...

Repopulation kinetics of erythrocytes and neutrophils and replacement of hematopoietic progenitors were studied in genetically anemic (WB x C57BL/6)F1-W/Wv (WBB6F1-W/Wv) hosts after bone marrow transplantation from C57BL/6-bgJ/bgJ or C57BL/6-bgJ/bgJ;Pgk-1a/Y mice. Electrophoretic pattern of hemoglobin was used as a marker of donor-type erythrocytes, giant granules of bgJ/bgJ mice as a marker of...

The hematological findings of 233 patients with brucellosis are presented and the possible pathologies discussed. Anemia was present in 128 patients (55%), leukopenia in 49 (21%) and thrombocytopenia in 59 (26%). Bone marrow aspirates of 18 patients (8%) with pancytopenia were examined. The bone marrow was hypercellular in 15 and normocellular in 3 patients. Granulomatous lesions were detected ...

The functions of resident macrophages (MO)' in hematopoietic and lymphoid organs are poorly understood . In several species, in situ immunocytochemical staining with MO-specific mAbs has demonstrated that these tissues contain large numbers of stromal MO, even in the absence of overt inflammation or immune stimulation (1-6). We and others have previously speculated that stromal MO may perform d...

The functions of resident macrophages (MO)' in hematopoietic and lymphoid organs are poorly understood . In several species, in situ immunocytochemical staining with MO-specific mAbs has demonstrated that these tissues contain large numbers of stromal MO, even in the absence of overt inflammation or immune stimulation (1-6). We and others have previously speculated that stromal MO may perform d...

Methyl isocyanate (MIC) was tested for genetic toxicity in a variety of in vitro and in vivo assays. Negative results were obtained in the Salmonella/mammalian microsome assay using five bacterial strains in a preincubation protocol. The Drosophila sex-linked recessive lethal test also gave negative results in studies that involved three routes of administration: inhalation, feeding, and inject...