Both invasive and non-invasive motor cortex stimulation techniques have been successfully employed in the treatment of chronic pain, but the precise mechanism of action of such treatments is not fully understood. It has been hypothesized that a mismatch of normal interaction between motor intention and sensory feedback may result in central pain. Sensory feedback may come from peripheral nerves...

Whereas the human right hemisphere is active during execution of contralateral hand movements, the left hemisphere is engaged for both contra- and ipsilateral movements, at least for right-handed subjects. Whether this asymmetry is also found during motor learning remains unknown. Implicit sequence learning by the nondominant left hand was examined with the serial reaction time (SRT) task durin...

1 Bernstein Center for Computational Neuroscience, Humboldt University, and Cluster of Excellence NeuroCure, Charité-Universitätsmedizin, Berlin, Germany 2 Department of Organismal Biology and Anatomy, Committees on Computational Neuroscience and Neurobiology, University of Chicago, Chicago, IL, USA 3 Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyot...

In 1991 Tsubokawa and colleagues first published their landmark results from a series in which epidural motor cortex stimulation (MCS) was used in the treatment of eight patients with central and neuropathic pain. In ensuing studies authors have elaborated on the indications, technique, hypotheical mechanisms, and beneficial results of this treatment. Epidural MCS is effective for trigeminal ne...

The motor cortex is often considered the main controller for movement, but a new study shows that well-trained paw movements can be performed with equal precision after lesions of the entire motor cortex; the motor cortex is, however, required for learning a new task in naïve animals.

The influence of motor cortex on muscles during different behaviors is incompletely understood. In this issue of Neuron, Miri et al. (2017) show that the population activity patterns produced by motor cortex during different behaviors determine the selective routing of signals along different pathways between motor cortex and muscles.

The primary motor cortex is a critical node in the network of brain regions responsible for voluntary motor behavior. It has been less appreciated, however, that the motor cortex exhibits sensory responses in a variety of modalities including vision and somatosensation. We review current work that emphasizes the heterogeneity in sensorimotor responses in the motor cortex and focus on its implic...

The concept of a separate premotor cortical field involved in the cerebral control of movement went out of favor among neurophysiologists during the quarter century from 1952 to 1977, but recent studies have led to its rehabilitation. The premotor cortex appears to be one of at least three fields within the motor cortex, two others being the primary motor cortex and the supplementary motor cort...

Elaboration of appropriate responses to behavioral situations rests on the ability of selecting appropriate motor outcomes in accordance to specific environmental inputs. To this end, the primary motor cortex (M1) is a key structure for the control of voluntary movements and motor skills learning. Subcortical loops regulate the activity of the motor cortex and thus contribute to the selection o...

Objectives: The aim of this article is to explain the detailed methodology record Motor evoked potential (MEP) and somatosensory (SSEP) in adult albino Wistar rat, male (200–250 g) which has not been defined previously. Materials Methods: We have standardised recording both MEP SSEP these rats under anaesthesia on ADI digital polyrite system. Results: Evoked potentials widely studied spinal cor...