The use of morphine analgesics is associated with a number side effects, especially morphine-induced gastrointestinal dysfunction. Gastrointestinal effects have negative impact on patient quality life. complex relationship between nicotine and opioids controversial one still not well understood. Some animal studies suggest that binds some opioid receptors. aim this study was to prospectively co...

There are several conflicting evidences showing the effect of morphine on learning and memory processes. In the present study the effect of chronic morphine administration on passive avoidance, active avoidance and spatial learning and memory of morphine dependent male rats using Passive Avoidance shuttle box and Morris Water Maze tasks were investigated, respectively. Male rats received morphi...

OBJECTIVE Rapid diagnosis of acute cholecystitis is essential to minimize morbidity and mortality. The purpose of this study was to assess the diagnostic utility of cholescintigraphy using morphine augmentation compared with ultrasound, in acute and chronic gallbladder disease. METHODS Cholescintigrams were performed on 103 patients suspected of having acute cholecystitis. In 79 patients (Gro...

hanges in the concentration of either brain or blood glucose level appear to modulate antinociceptive and basal nociceptive processes. There are some contradictory data about the effect of diabetes on morphine antinociception. In this study the effects of alloxan-induced diabetes on morphine analgesia, tolerance and dependency were investigated, with a view to clarify the contradictions. Materi...

introduction: methadone has been used as a drug to detoxify opioid tolerance. naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. on the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in drinking...

Introduction: It has been reported that oral morphine dependency facilitated formation of spatial learning and memory. In the present study the role of NMDA receptors located in hippocampal CA1 area of morphine dependent rats was studied. Methods: Male rats were divided into 4 groups. Two cannulae were stereotaxically implanted bilaterally into the hippocampal CA1 area. After 5 days recover...

introduction: pain control is the most important issue in emergency department management of patients with femoral bone fractures. the present study aimed to compare the procedural features of ultrasonography and nerve stimulator guided femoral nerve block in this regard. method: in this randomized clinical trial, patients with proximal femoral fractures presenting to emergency department were ...

BACKGROUND Spinally administered opioids show decreased potency and efficacy in the treatment of neuropathic pain. As reported previously, morphine stimulates spinal opioid receptors to effect adenosine release, which acts at adenosine receptors to produce analgesia. The authors hypothesized that morphine induces less adenosine release in neuropathic compared with normal rats, explaining its re...

The analgesic activity of ethanolic extract of Justicia beddome leaves (Family: Acanthaceae) was evaluated in albino rats using Eddy's hot plate method. The extract at 50 and 100 mg/ kg, (i.p), showed significant analgesic activity at 90 minutes of administration. The analgesic effect of the extract was comparable to that of morphine sulphate.

ft. ? c^aP^er H while dealing with intravenous anaesthesia, author's experience and practical tips about evipan sodium would have been appreciated. Regarding pentothal sodium he has not mentioned whether premedication with drugs like omnopen, morphine sulphate, etc., is necessary or not. Excepting a few such minor points, the book will be found a valuable guide and help for beginner and profess...