We herein describe four cases of patients with Parkinson's disease who were treated with istradefylline (ISD) in the evening and had severe daytime sleepiness. The time to onset of sleepiness varied between 2 weeks to 3 months. All patients recovered after changing the timing of the ISD dosage from evening to morning. ISD is an A2A receptor antagonist with a caffeine-like arousal effect that ma...

Sleep-disordered breathing may occur in a wide variety of neuromuscular syndromes, and may present with diverse, often isolated, symptoms or findings such as excessive daytime sleepiness, pulmonary hypertension, congestive heart failure, morning headaches, or hypoxia-induced nocturnal seizures. The authors report two sisters with congenital muscular dystrophy in whom central sleep apnoea result...

conclusions no significant differences were observed between the groups based on the neonatal outcome including neonatal anthropometric parameters and lack of congenital anomaly. results there was no difference between the groups in the mean age of mother and the mean age of gestation. no differences were found between the groups regarding birth weight (3006.93 ± 441.86 versus 2949.65 ± 457.36 ...

shiftwork is now a major feature of working life across a broad range of industries and circadian rhythms play an important role in shiftwork tolerance. so, the aim of this study was examine the relationships between age, morning-type and rigidity sleeping habits with shiftwork tolerance among shiftworkers of karun oil and gas exploitation company. the sample consisted of 295 shiftworkers of ah...

      Background & Aims of the Study: According to the report of world health, organization mental disorder is one of the important causes of disability in the world and it can result in decrease in the success and advancement of employees. Thus, the purpose of this research is evaluation and comparison of mental health status and its related factors in female emplo...

Morning Report is a time-honored tradition where physicians-in-training present cases to their colleagues and clinical experts collaboratively examine an interesting patient presentation. The section seeks carry on this by presenting patient’s chief concern story, inviting the reader develop differential diagnosis discover alongside authors of case.This report examines story 43-year-old (gravid...