We systematically studied the intramural nervous system of the alimentary tract in patients with Parkinson's disease and found that Lewy bodies were distributed widely in the Auerbach's and Meissner's plexuses. In the central nervous system, we recognized a striking similarity between the distribution of Lewy bodies and that of monoaminergic neurons. More recently, we have demonstrated that neu...

The monoaminergic neurotransmitters dopamine, noradrenaline, and serotonin are pivotal actors of the interplay between nervous immune system due to their ability binding cell-receptors both systems, crucially regulating function within central periphery. As monoamines dysfunctional in many neurological psychiatric diseases, they have been successfully used as pharmacological targets. Multiple s...

Methyl parathion induced alterations in the level of monoamines, viz. norepinephrine, dopamine and serotonin were studied in discrete regions of developing central nervous system of rat pups. A significant decrease in the level of monoamines noticed in methyl parathion toxicosis may be related to the altered neuronal activity and inefficiency, leading to depression and impairment in various beh...

The circadian system coordinates activities and functions in cells and tissues in order to optimize body functions in anticipation to daily changes in the environment. Disruption of the circadian system, due to irregular lifestyle such as rotating shift work, frequent travel across time-zones, or chronic stress, is correlated with several diseases such as obesity, cancer, and neurological disor...

The vast majority of illicit stimulants act at monoaminergic systems, causing both psychostimulant and adverse effects. Stimulants can interact as substrates or antagonists the nerve terminal monoamine transporter that mediates reuptake monoamines across synaptic membrane vesicular (VMAT‐2) storage in vesicles. directly presynaptic postsynaptic receptors for have indirect monoamine‐mimetic acti...

Individual variation in behavioral coping strategies to stress implies that animals may have a distinct physiological adaptation to stress; these differences may underlie differences in vulnerability to stress-related diseases. This study was designed to test the hypothesis that different behavioral coping strategies (active vs. passive) are stable over time and that they would be associated wi...