In this study, we aimed to determine VEGFR-2, EGFR and PDGFR-β tyrosine kinase inhibitory activities of some pyrrolo[2,3-d]pyrimidine derivatives previously synthesized and showed potent cytotoxic and apoptotic effects against several cancer cell lines by our group and to evaluate the relationships between inhibitory activities and binding properties of the active compounds by molecular docking...

The effect of nanofluids on chaotic convection in a fluid layer heated from below was studied in this paper for low Prandtl number based on the theory of dynamical systems. A low-dimensional, Lorenz-like model was obtained using Galerkin-truncated approximations. The fourth-order Runge-Kuttamethodwas employed to solve the nonlinear system. The results show that inhibition of chaotic convection ...

The present research article relates to the discovery of the novel drugs based on Zonisamide to treatment of autism disease. In first step, the electronic properties, reactivity and stability of the said compound are discussed. To attain these properties, the said molecular structure is optimized using B3LYP/6-311++G(d,p) level of theory at room temperature. The frontier molecular orbitals (FMO...

Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

An empirical electrical conductivity assessment of nanofluids comprising CuO nanoparticles water-based in different concentrations, particles size and various temperatures of nanofluids has been carried out in this paper. These experimentations have been done in deionized water with nanoparticles sizes such as 89, 95, 100 and 112 nm and concentrations of 0.12 g/l, 0.14 g/l, 0.16 g/l and 0.18 g/...

Deoxyribonucleic acid (DNA) is an important molecular target for anti-cancer agents due to its involvement in gene expression and protein synthesis which are fundamental steps in cell division and growth. A number of antineoplastic agents interfere with DNA and hence disturb the cell cycle. Compounds including planar aromatic rings are privileged scaffolds in binding to the DNA. This characteri...

In the present work, we investigated the scattering and spectrally resolved absorption properties of nanofluids consisting in aqueous and glycol suspensions of single-wall carbon nanohorns. The characteristics of these nanofluids were evaluated in view of their use as sunlight absorber fluids in a solar device. The observed nanoparticle-induced differences in optical properties appeared promisi...

In this study, the effect of concentration of nanoparticles on the thermal storage properties of molten nitrate salt-based nanofluids with graphene nanoplatelets (GNPs) was investigated. Solar salt consisting of sodium nitrate and potassium nitrate was utilized as the base material for the nanofluids. Homogeneous dispersion of GNPs within the solar salt was observed through scanning electron mi...

A one-parameter model is presented for the thermal conductivity of nanofluids containing dispersed metallic nanoparticles. The model takes into account the decrease in thermal conductivity of metal nanoparticles with decreasing size. Although literature data could be correlated well using the model, the effect of the size of the particles on the effective thermal conductivity of the nanofluid c...