OBJECTIVE To perform a serial assessment and compare ability in predicting the intensive care unit (ICU) mortality of the multiple organ dysfunction score (MODS), sequential organ failure assessment (SOFA) and logistic organ dysfunction (LOD) score. MATERIAL AND METHOD The data were collected prospectively on consecutive ICU admissions over a 24-month period at a tertiary referral university ...

Nutritional and environmental epigenetics are involved with the repression of anti-aging genes that are linked to the chronic disease epidemic. Unhealthy diets inactivate the calorie sensitive gene Sirtuin 1 (Sirt 1) involved in epigenetic processes that promote immune system alterations, mitochondrial apoptosis, Non-alcoholic Fatty Liver Disease (NAFLD), diabetes and Nitric Oxide (NO) modifica...

Driving a vehicle along a route consists of control actions applied to the vehicle by taking into account the vehicle and route states. Control actions are usually selected by optimizing the traveling time and the fuel consumption. However, the resulting vehicle behavior can be uncomfortable for the driver/passengers. The comfort is measured as the change of acceleration, i.e., jerk. To obtain ...

The aim of our study was to evaluate the effect of continuous renal replacement therapy (CRRT) on serum cytokines, neutrophil gelatinase-associated lipocalin (NGAL), and prognosis in patients with severe acute kidney injury (AKI) following cardiac surgery. A total number of 153 patients with severe AKI following cardiac surgery were treated with CRRT. They were divided into the survival and non...

Background: Interleukin 6 (IL-6) functions as both a pro-inflammatory cytokine and an anti-inflammatory cytokine. Objective: To evaluate the levels of IL-6 in patients with multiple organ dysfunction syndrome (MODS). Methods: Level of IL-6 was assessed and recorded for 14 days subsequent to the injury in 161 multiple trauma patients. MODS were diagnosed using Marshal Score. Injury Severity Scor...

Aim & Objectives: Prospective study to evaluate the mortality prediction in patients with perforation peritonitis using APACHE II, SAPS II, MODS, SOFA and MPI scoring systems. Material and Methods: One hundred patients of hollow viscus perforation peritonitis, from October 2012 – June 2014, were evaluated preoperatively using above mentioned scores and outcome noted in terms of mortality; there...

OBJECTIVE To review the findings and discuss the implications of transfusion strategies in stable critically ill children. DESIGN A critical appraisal of the article "Transfusion strategies for patients in pediatric intensive care units" by Lacroix J, Hebert PC, Hutchison, et al, published in the N Engl J Med in 2007 with literature review. FINDINGS In this prospective, randomized, controll...

OBJECTIVES: The relation of procalcitonin (PCT) plasma concentrations compared with C-reactive protein (CRP) was analyzed in patients with different severity of multiple organ dysfunction syndrome (MODS) and systemic inflammation. PATIENTS AND METHODS: PCT, CRP, the sepsis-related organ failure assessment (SOFA) score, the Acute Physiology, Age, Chronic Health Evaluation (APACHE) II score and s...

A study was carried out to compare the performance of a commercial method (MGIT) and four inexpensive drug susceptibility methods: nitrate reductase assay (NRA), microscopic observation drug susceptibility (MODS) assay, MTT test, and broth microdilution method (BMM). A total of 64 clinical isolates of Mycobacterium tuberculosis were studied. The Lowenstein-Jensen proportion method (PM) was used...

OBJECTIVE To investigate the effects of hemodialysis (HD) and hemoperfusion (HP) on inflammatory factors and nuclear transcription factors in peripheral blood cell of multiple organ dysfunction syndrome (MODS) patients. PATIENTS AND METHODS 92 cases of MODS patients undergoing maintained hemodialysis in our hospital were randomly divided into the control group and observation group. The contr...