SUMMARY DNA copy number alterations (CNA) frequently underlie gene expression changes by increasing or decreasing gene dosage. However, only a subset of genes with altered dosage exhibit concordant changes in gene expression. This subset is likely to be enriched for oncogenes and tumor suppressor genes, and can be identified by integrating these two layers of genome-scale data. We introduce DNA...

Quantum mechanics is an excellent technique to counter and study the effect of noise in any system. A digital integrator can be designed with the help of quantum mechanics by passing a known signal ( ) to a known digital integrator, with impulse response ( ) and then, the output of this integrator ( ) is given to the input of a known quantum system (specified by its Hamiltonian ( ), perturbatio...

In this work, a prescribed-time second-order sliding mode (SOSM) controller is constructed to address class of nonlinear systems in the presence asymmetric output constraints. To handle constraints, frequently-used barrier Lyapunov function employed. Meanwhile, time-varying scaling introduced ensure convergence closed-loop system. On basis, SOSM by inserting BLF and into modified power integrat...

medicine, health John Weeks has been active as a writer, organizer, executive, consultant, and speaker in the movement for integrative health and medicine for more than 30 years. His leadership-focused Integrator Blog News and Reports (theintegratorblog.com) and now his Global Integrator Blog are go-to sources on breaking developments in policy, business, academics, and interprofessional activity.

The aim of this paper is to present one type of pole assignment controller that is based on the analysis of optimal settings for the double integrator system. It takes into account parasitic delays in the control structure and constraints imposed on the control signal. The whole design is illustrated on two examples. Key-Words: Pole assignment control, constraints, saturation, double integrator...

The Switched Capacitor (SC) Integrator mentioned in this paper, is part of a test chip that has been designed in 0.5 μm CMOS technology. With this novel test structure, precision investigations on major nonidealities in such a circuit can be performed. Keywords— SC integrator, analog CMOS switch, channel charge, clock feed-through.

Since almost twenty years, modified Patankar–Runge–Kutta (MPRK) methods have proven to be efficient and robust numerical schemes that preserve positivity conservativity of the production-destruction system irrespectively time step size chosen. Due these advantageous properties they are used for a wide variety applications. Nevertheless, until now, an analytic investigation stability MPRK is sti...

We introduce a new electrostatic particle-in-cell algorithm capable of using large timesteps compared to particle gyro-period under uniform external magnetic field. The extends earlier fully implicit PIC implementations with asymptotic-preserving particle-push scheme that allows much larger than gyroperiods. In the large-timestep limit, integrator preserves all drifts, while recovering full orb...

Over the years, systematic search for stiff model solvers that are near-optimal has attracted attention of many researchers. An attempt been made in this research to formulate an implicit Four-Point Hybrid Block Integrator (FPHBI) simulations some renowned rigid models. The integrator is formulated by using Lagrange polynomial as basis function. properties which include order, consistency, and ...

Hematopoiesis, the dynamic process of blood cell development, is regulated by the activity of the bone morphogenetic protein (BMP) signaling pathway and by many transcription factors. However, the molecules and mechanisms that regulate BMP/Smad signaling in hematopoiesis are largely unknown. Here, we show that the Integrator complex, an evolutionarily conserved group of proteins, functions in z...