PURPOSE We evaluated the effect of human parathyroid hormone (hPTH) on the engraftment and/or in vivo expansion of hematopoietic stem cells in an umbilical cord blood (UCB)-xenotransplantation model. In addition, we assessed its effect on the expression of cell adhesion molecules. MATERIALS AND METHODS Female NOD/SCID mice received sublethal total body irradiation with a single dose of 250 cG...

BACKGROUND Several activities are attributed to antimicrobial peptides (AMPs), including bacterial killing, leucocyte recruitment and angiogenesis. Despite promises of advanced cellular therapies for treatment of diabetic foot ulcer, it is currently accepted that paracrine factors rather than cellular components are causative for the observed effects. Whether AMPs are present in the mononuclear...

Hematopoietic cord blood (CB) stem cell transplantation has more advantages to other cell sources because of lower Graft Versus Host Disease (GVHD). Interleukin-15(IL-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord Natural Killer (NK) cells. The aim of this study was to investigate the effect of IL-15 on NK cytotoxicity simultaneously in different cell death sta...

BACKGROUND Bronchopulmonary dysplasia (BPD) presents a major threat of very preterm birth and treatment options are still limited. Stem cells from different sources have been used successfully in experimental BPD, induced by postnatal hyperoxia. OBJECTIVES We investigated the effect of umbilical cord blood mononuclear cells (MNCs) in a new double-hit mouse model of BPD. METHODS For the doub...

BACKGROUND Enrichment and purification of hematopoietic stem and progenitor cells (HSPCs) is important in transplantation therapies for hematologic disorders and in basic stem cell research. Primitive CD34+ HSPCs have demonstrated stronger rolling adhesion on selectins than mature CD34- mononuclear cells (MNCs). We have exploited this differential rolling behavior to capture and purify HSPCs fr...

Isolated extramedullary relapse in childhood acute lymphoblastic leukemia (ALL) may be accompanied by occult bone marrow disease. We used a highly sensitive assay to quantify leukemic progenitor cells (LPCs) in the bone marrow of such patients. Multiparameter flow cytometry and blast colony assays were used to detect LPCs in the bone marrow of 31 pediatric B-lineage ALL patients with an isolate...

Endothelial dysfunction is characterized by abnormalities in vasoreactivity and is a marker of the extent of atherosclerosis. Cellular repair by circulating progenitor cells of ongoing vascular injury may be essential for vascular integrity and function and may limit abnormalities in vasoreactivity. Apolipoprotein E-deficient (apoE-/-) mice were splenectomized and treated with high-cholesterol ...

Introduction The enlargement of the EU to ten new countries, of which eight postcommunist countries with significantly lower labour costs, has increased the opportunities for international reorganisation of production for multinational companies (MNCs) and, with this, for ‘coercive comparisons’ and efficiency-oriented transfers of practices. This paper discusses the dynamics in place through tw...

Magnesium matrix nanocomposites (Mg-MNCs) are high grade materials widely used in aerospace, electronics, biomedical and automotive sectors for strength to weight ratio, excellent sustainability superior mechanical tribological characteristics. Basic properties of Mg-MNCs rely on type amount reinforcement fabrication process. Current study reviews existing literatures explore contribution diffe...

a r t i c l e i n f o Keywords: High performance work system Host country nationals Relational psychological contract Job performance This study argues that multinational corporations (MNCs) which implement high performance work system in their host country nationals may help their workers form relational psychological contracts with the MNC. Such practices can increase host country national wo...