نتایج جستجو برای: mlck

تعداد نتایج: 574  

2016
Xiaolin Zhang Hao Yu

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosis-inducing effect of matrine on tu...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2003
Hui-Ping Tzeng Rong-Sen Yang Tzuu-Huei Ueng Shoei-Yn Lin-Shiau Shing-Hwa Liu

The effects of motorcycle exhaust particulate on vasoconstriction were determined using rat thoracic aortas under organ culture conditions treated with organic extracts of motorcycle exhaust particulate from a two-stroke engine. The motorcycle exhaust particulate extract (MEPE) induced a concentration-dependent enhancement of vasoconstriction elicited by phenylephrine in the organ cultures of b...

Journal: :The Journal of Cell Biology 1990
M O Shoemaker W Lau R L Shattuck A P Kwiatkowski P E Matrisian L Guerra-Santos E Wilson T J Lukas L J Van Eldik D M Watterson

The first primary structure for a nonmuscle myosin light chain kinase (nmMLCK) has been determined by elucidation of the cDNA sequence encoding the protein kinase from chicken embryo fibroblasts, and insight into the molecular mechanism of calmodulin (CaM) recognition and activation has been obtained by the use of site-specific mutagenesis and suppressor mutant analysis. Treatment of chicken an...

2014
Hannah L Dewerchin Lowiese M Desmarets Ytse Noppe Hans J Nauwynck

Monocytes infected with feline infectious peritonitis virus, a coronavirus, express viral proteins in their plasma membranes. Upon binding of antibodies, these proteins are quickly internalised through a new clathrin- and caveolae-independent internalisation pathway. By doing so, the infected monocytes can escape antibody-dependent cell lysis. In the present study, we investigated which kinases...

1999
THOMAS Y. MA DON NGUYEN VUONG BUI HANH NGUYEN Don Nguyen Vuong Bui Hanh Nguyen

Ma, Thomas Y., Don Nguyen, Vuong Bui, Hanh Nguyen, and Neil Hoa. Ethanol modulation of intestinal epithelial tight junction barrier. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G965–G974, 1999.—Previous studies have shown that high concentrations of ethanol ($40%) cause functional damage of the gastrointestinal epithelial barrier by direct cytotoxic effect on the epithelial cells. Th...

2016
Shun-gen Huang Wan-liang Guo Zhi-cheng Zhou Jun-jie Li Fu-bin Yang Jian Wang

BACKGROUND In pancreaticobiliary maljunction (PBM), the sphincter of Oddi can not control bile and pancreatic juice flow, which may lead to two-way reflux of bile and pancreatic juice, thus causing chronic inflammation, thickening, fibrosis and metaplasia of the common bile duct wall. These pathophysiological changes have been linked to disruption of the epithelium barrier in the common bile du...

Journal: :FEBS letters 2007
Ellen L Batchelder Christina L Thomas-Virnig Jeffery D Hardin John G White

Furrow ingression in animal cell cytokinesis is controlled by phosphorylation of myosin II regulatory light chain (mRLC). In Caenorhabditis elegans embryos, Rho-dependent Kinase (RhoK) is involved in, but not absolutely required for, this phosphorylation. The calmodulin effector myosin light chain kinase (MLCK) can also phosphorylate mRLC and is widely regarded as a candidate for redundant func...

Journal: :The Biochemical journal 2005
David P Wilson Cindy Sutherland Meredith A Borman Jing Ti Deng Justin A Macdonald Michael P Walsh

Smooth muscle contraction is activated by phosphorylation at Ser-19 of LC20 (the 20 kDa light chains of myosin II) by Ca2+/calmodulin-dependent MLCK (myosin light-chain kinase). Diphosphorylation of LC20 at Ser-19 and Thr-18 is observed in smooth muscle tissues and cultured cells in response to various contractile stimuli, and in pathological circumstances associated with hypercontractility. ML...

2015
Niamat Khan D. V. Krishna Pantakani Lutz Binder Muhammad Qasim Abdul R. Asif

BACKGROUND Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients, however, its use is also associated with adverse side effects like sporadic gastrointestinal (GI) disturbances. Recently, we reported the MPA induced tight junctions (TJs) deregulation which involves MLCK/MLC-2 pathway. Here, we investigated t...

Journal: :Journal of Cell Biology 2015

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