Results obtained with BeppoSAX observations of blazars within various collaborative programs are presented. The spectral similarity “paradigm”, whereby the spectral energy distributions of blazars follow a sequence, leading to a unified view of the whole population, is briefly illustrated. We concentrate on recent observations of flares and associated spectral variability long for three objects...

The recent detection of gamma radiation from Mkn 501 at energies as high as ∼ 25 TeV suggests stringent upper bounds on the diffuse, far infrared, extragalactic radiation density. The production of electron-positron pairs through photon-photon collisions would prevent gamma photons of substantially higher energies from reaching us across distances of order 100Mpc. However, coherently arriving T...

Survivin plays an important role in cancer development. We aim to show here that suppression of survivin expression or function by antisense and dominant-negative (DN) mutant can inhibit gastric cancer carcinogenesis and angiogenesis in vivo. Plasmid constructs expressing survivin antisense and DN mutant replacing the cysteine residue at amino acid 84 with alanine (Cys84Ala) were prepared and i...

Introduction: Gastric cancer is one of the most commonly known malignancies and fifth cancer-related death globally. Whereas natural killer (NK) cells play a critical role in tumor elimination; therefore, adoptive NK cell therapy has become promising approach cytotherapy. Hence, this study investigated chemo-immune MKN-45 derived xenograft gastric model. Methods: Three groups animals have recei...

We present a new method to reconstruct the arrival direction of individual air showers. The method is based in part on the arrival direction reconstruction method of Lessard et al. [1] from the Whipple collaboration, but yields a significant 30% improvement in the obtained angular resolution. The method was successfully tested on Monte Carlo Simulations and real data of Mkn 421, Mkn 501 and 1ES...

We present results of narrow-band and broad-band optical CCD imaging together with intermediate-resolution spectroscopy of the Wolf-Rayet galaxy Mkn 8. Analysis of the morphology and kinematics of the object indicates that the strong star formation episode we are witnessing in Mkn 8 is the product of the interaction of two (or three) disk galaxies. The chemical abundances and abundance ratios m...

The Sonic Hedgehog (Shh) signaling pathway is commonly activated in gastrointestinal cancer. However, our understanding of the Shh pathway in gastric cancer remains limited. Here we examined the effects of cyclopamine, a specific inhibitor of the Shh signaling pathway, on cell growth and proliferation in gastric primary cancer cells GAM-016 and the MKN-45 cell line. The results showed that the ...

The BL Lac Object Mkn 501 was in a state of high activity in the TeV range in 1997. During this time Mkn 501 was observed by all Cherenkov-Telescopes of the HEGRA-Collaboration. Part of the data were also taken during moonshine thus providing a nearly continuous coverage for this object in the TeV-range. We have carried out a QPO analysis and found evidence for a 23 day periodicity. We applied ...

The extremely rapid burst of TeV photons from Mkn 421 (15 May 1996) can be reconciled with the standard properties of a relativistic γ-ray emitting jet (bulk Lorentz factor Γ ∼ 10; size ∼ 10 cm) if one assumes that the electrons are accelerated in conical shocks with both opening and viewing angles ≈ 1/Γ. If the injection time and the cooling time are much less than the photon crossing time, an...