Many intracellular bacterial pathogens naturally release membrane vesicles (MVs) under a variety of growth environments. For pathogenic bacteria there are strong evidences that released MVs are a delivery mechanism for the release of immunologically active molecules that contribute to virulence. Identification of membrane vesicle-associated proteins that can act as immunological modulators is c...

The literature suggests that investors prefer portfolios based on mean, variance and skewness rather than portfolios based on mean-variance (MV) criteria solely. Furthermore, a small variety of methods have been proposed to determine meanvariance-skewness (MVS) optimal portfolios. Recently, the shortage function has been introduced as a measure of efficiency, allowing to characterize MVS optima...

COVID-19 is a respiratory infectious disease that spreads readily between people, and an urgent issue of passengers’ exposure risk assessment in commercial aircraft has been raised because cabin as confined space may carry transmit the worldwide. In this study, droplets transmission process under different ventilation systems twin-aisle wide-body was studied using CFD simulations infection pass...

OBJECTIVE To investigate the effects of circulating microvesicles derived from myocardial ischemia (I-MVs) on apoptosis in myocardial ischemia/reperfusion (I/R) injury in rats. METHODS I-MVs from rats undergoing myocardial left anterior descending (LAD) coronary artery ligation were isolated by ultracentrifugation from circulating blood and characterized by flow cytometry. I-MVs were administ...

BACKGROUND Public health officials recommend that women capable of becoming pregnant use folic acid-containing supplements (FAS) to prevent neural tube defects (NTD) in their newborn infants. However, the knowledge about NTD prevention and the prevalence of the use of FAS among women capable of becoming pregnant increased only modestly since the issuing of the recommendation in 1992. Since most...

PURPOSE To evaluate the impact of continuous manufacturing process improvements on glistening formation in AcrySof hydrophobic acrylic intraocular lenses (IOLs) by comparing lenses manufactured in 2003 with lenses manufactured in 2012. METHODS Glistenings were experimentally created as aqueous-filled microvacuoles utilizing an accelerated laboratory method by immersing the lens in water at 45...

Tumor-secreted extracellular vesicles (EVs) including microvesicles (MVs) and exosomes, classified according to their sub-cellular origin [1], are critical mediators of intercellular communication between malignant cells and cells in local and distant microenvironments supporting metastatic niche formation. Clinically, EVs may be biomarkers and novel therapeutic targets that reflect cancer prog...

Senescence in human mesenchymal stem cells (MSCs) not only contributes to organism aging and the development of a variety of diseases but also severely impairs their therapeutic properties as a promising cell therapy. Studies searching for efficient biomarkers that represent cellular senescence have attracted much attention; however, no single marker currently provides an accurate cell-free rep...

Microvesicles (MVs) are released by most cell types in physiological conditions, but their number is often increased upon cellular activation or neoplastic transformation. This suggests that their detection may be helpful in pathological conditions to have information on activated cell types and, possibly, on the nature of the activation. This could be of paramount importance in districts and t...