Background: Melanoma is a malignant neoplasia that shows high mortality when diagnosed in advanced stages. Early identification of high-risk patients for the development of melanoma metastases is the main strategy to reduce mortality. oBjective: To assess the influence of eight epidemiological and histopathologic features on the development of metastases in patients diagnosed with primary cutan...

BACKGROUND The National Comprehensive Cancer Network (NCCN) recommends conservative follow-up for gastric gastrointestinal stromal tumors (GISTs) less than 2 cm. The aim of the present study was to investigate the clinical and pathological features of small gastric GISTs, re-evaluate the risk potential, and discuss the treatment strategy of small gastric GISTs. METHODS In this retrospective s...

PURPOSE To investigate the changes in the intestinal epithelium of rats, when submitted to the ischemia of varied time and scheduled reperfusion. METHODS For this purpose, the following groups were established six groups: control, 10, 20, 30, 40, 60 minutes of ischemia and reperfusion time (24 hours). Their intestines being resected for histopathological analysis: the length and width of the ...

The effects of some endocrine disruptors that possess estrogen-like activity on the secretion and growth of regenerating rat adrenal cortex have been investigated in ovariectomized (OVX) and sham-OVX rats. As reference groups, dexamethasone (Dx)-administered sham-OVX and 17beta-estradiol-administered OVX animals were used. Dx, estradiol and endocrine disruptors were subcutaneously injected dail...

Polymorphisms of the p53 gene, which participates in DNA repair, can affect the functioning of the p53 protein. The Arg and Pro variants in p53 codon 72 were shown to have different regulation properties of p53-dependent DNA repair target genes that can affect various levels of cytogenetic aberrations in chronic hepatitis B patients. The present study aimed to examine the frequency of chromosom...

The development of the cranial neuromeres, rostral to the level of the first somite, in rat embryos during neurulation is described. Examination of scanning electron micrographs of 4-, 8-, 12- and 16-somite-stage embryos has shown that the neuromeres develop in a strictly ordered pattern but the sequence is not ordered in either a rostrocaudal or caudorostral direction. The two mesomeres are sh...

This article discusses the natural history, clinical epidemiology, diagnosis, and treatment of radiation-induced lung diseases (RILDs). Furthermore, we review current experimental developments and assess potential areas for future investigation. Radiation therapy (RT) is a key component of the approach to the treatment of thoracic neoplasms. The use of radiation for the treatment of cancer expl...

Atonal homolog 1 (Atoh1) is crucial to the differentiation of many cell types and participates in tumorigenesis and progression. However, the expression of Atoh1 in gastrointestinal stromal tumors (GIST) and its relationship to clinical characteristics of this disease remain poorly understood. In this study, immunohistochemical analysis using tissue microarray (TMA) was employed to evaluate the...

objective(s):fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. the aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin b1 (fb1).    materials and methods: twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. the treatment gro...

Chronic atrophic gastritis, chronic duodenal and gastric ulcers create conditions for the formation of precancerous changes in mucosa form dysplasia. The biopsy material from patients with - 75 was studied. development severe dysplasia epithelium observed mainly more forms gastritis. High proliferative activity confirmed by expression marker Ki-67 a label index (MI)>30,0%. Between degree muc...