UNLABELLED The aim of this study was to determine the human biodistribution and radiation dosimetry of (99m)Tc-RP527, a promising radioligand for the visualization of gastrin-releasing peptide (GRP) receptor-expressing human malignancies. METHODS Whole-body scans were obtained up to 48 h after intravenous injection of 555 MBq (99m)Tc-RP527 in each of 6 subjects. Blood samples were taken at va...

UNLABELLED Several radionuclides used in medical imaging emit Auger electrons, which, depending on the targeting strategy, either may be exploited for therapeutic purposes or may contribute to an unintentional mean absorbed dose burden. In this study, the virtues of 12 Auger electron-emitting radionuclides were evaluated in terms of cellular S values in concentric and eccentric cell-nucleus arr...

OBJECTIVES The Phase I safety, biodistribution and internal radiation dosimetry study in adult healthy Japanese males of flutemetamol ((18)F) injection, an in vivo β-amyloid imaging agent, is reported and compared with previously obtained Caucasian data. METHODS Whole-body PET scans of 6 healthy volunteers (age 51.8-61.7 years) were acquired approximately 4 h post-injection (administered acti...

In nuclear medicine and particularly in internal radiotherapy, one of the major challenges is to determine the dose for each patient. Current internal dosimetric estimations are based on the Medical Internal Radiation Dose (MIRD) formalism and use standard mathematical models. These standard models are often far from a given patient morphology and do not allow to perform patient-specific dosime...

Aim: Calculating the absorbed dose is important for the determination of risk and therapeutic benefit of internal radiation therapy. Optimal dose estimations require time-consuming and sophisticated methods, which are difficult due to practical reasons. To make dosimetry available for each of the patients, we developed a specific dosimetry procedure used in daily clinical routine. Materials and...

In recent years, specially designed patches containing beta emitters have been developed for contact brachytherapy of skin lesions. The aim of the present work was to evaluate the biological effects of the (32)P-patch on the skin of Sencar mice as a result of a brachytherapy treatment. For this purpose, a (32)P-patch was prepared with Chromic (32)P-phosphate and silicone and the classical model...

UNLABELLED The synthetic leucine amino acid analog anti-1-amino-3-(18)F-fluorocyclobutane-1-carboxylic acid (anti-(18)F-FACBC) is a recently developed ligand that permits the evaluation of the L-amino acid transport system. This study evaluated the whole-body radiation burden of anti-(18)F-FACBC in humans. METHODS Serial whole-body PET/CT scans of 6 healthy volunteers (3 male and 3 female) we...

In order to evaluate internal dose, MIRD system was proposed by Society of Nuclear Medicine in 1976. MIRDOSE3 computer software based on this concept is currently the most frequently used tool to calculate the organ dose in nuclear medicine community. Unfortunately it uses fixed anthropomorphic phantoms, so the geometric parameters of organs are short of individual characteristics. Although the...

Introduction: Stereotactic Gamma Knife radiosurgery has been widely used for treating brain tumors. The scattered radiation outside of treatment field (peripheral dose) can induce the secondary cancer to specific organ. This paper investigated the absorbed dose to eyes, thyroid, heart, lung, breast and colon using a Monte Carlo technique for Mird phantom. We also study the ef...