نتایج جستجو برای: mir 182 5p

تعداد نتایج: 56569  

Journal: :General Physiology and Biophysics 2023

Circular RNAs (circRNAs) are related to rheumatoid arthritis (RA) development. However, the function and mechanism of circRNA pituitary tumor-transforming 1 interacting protein (circ- PTTG1IP) in RA unknown. The expression circ-PTTG1IP synovial tissues patients fibroblast-like synoviocytes from (RA-FLSs) were detected by RT-qPCR. results uncovered that was overexpressed RA-FLSs, knockdown suppr...

Journal: :Cancer Cell International 2021

Abstract Background Cervical cancer is one most common types among females over the world. While its underlying mechanisms remain unclear. Circ-CCDC66 has been revealed to participate in multiple biological functions, and contribute various diseases’ progression. In current study, we aimed demonstrate role of circ-CCDC66 cervical Methods Real-time quantitative PCR (RT-qPCR) was conducted measur...

2018
Yali Huang Shengding Zhang Xiaoyu Fang Lu Qin Yu Fan Dandan Ding Xiansheng Liu Min Xie

OBJECTIVE We investigated the relationship between plasma miRNAs levels and inflammatory characteristics in asthmatic patients. METHODS Eligible adults with untreated asthma (n = 35) underwent a clinical assessment, sputum induction, and assessment of pulmonary function test and Asthma Control Test (ACT) scores. Asthma phenotypes were defined using the sputum cell count. miR-199a-5p expressio...

2017
Kai Wang Jun Jin Tengxiao Ma Hongfeng Zhai

Our study sought to clarify the effects of microRNA-139-5p (miR-139-5p) in the tumorigenesis and progression of oral squamous cell carcinoma (OSCC) by regulating HOXA9. MiR-139-5p and HOXA9 expression in OSCC tissues, tumour adjacent tissues, OSCC cells and normal cells were tested by qRT-PCR. SAS and CAL-27 cell lines were selected in among four OSCC cell lines and then transfected with miR-13...

Journal: :Molecular medicine reports 2015
Duqun Chen Yifan Li Zhengming Su Zuhu Yu Wenshui Yu Yuchi Li Yaoting Gui Shangqi Yang Yongqing Lai

miR‑125a‑5p has been previously described as a tumor suppressor in numerous malignancies, however the expression and function of miR‑125a‑5p in renal cell carcinoma (RCC) remains to be elucidated. In the present study, to explore the potential role of miR‑125a‑5p in RCC, quantitative polymerase chain reaction was used to determine the expression levels of miR‑125a‑5p in renal cancer tissues. Th...

2016
Shi-Bin Jiang Xu-Jun He Ying-Jie Xia Wei-Jian Hu Jun-Gang Luo Jun Zhang Hou-Quan Tao

MicroRNA (miR)-145-5p has been reported to function as a suppressor of cancer and plays an important role in cancer invasiveness. Epithelial-mesenchymal transition (EMT) is an important process in cancer invasion and migration. However, the involvement of miR-145-5p in EMT in human gastric cancer (GC) remains unclear. In this study, we aimed to investigate the molecular mechanisms by which miR-...

2017
Xu Han Hexige Saiyin Junjie Zhao Yuan Fang Yefei Rong Chenye Shi Wenhui Lou Tiantao Kuang

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and malignant neoplasm. The aberrant expression of miR-135b-5p and secreted frizzled-related protein 4 (SFRP4) has been revealed to be involved in various cancers. However, the clinical significance of miR-135b-5p and that of its potential target SFRP4 in PDAC remain to be elucidated. Here, we found that miR-135b-5p was markedly upr...

2017
Cristina Borzi Linda Calzolari Giovanni Centonze Massimo Milione Gabriella Sozzi Orazio Fortunato

Lung cancer is the most frequent cause of cancer-related death worldwide, with limited therapeutic options and rapid development of drug resistance. MicroRNAs, a class of small non-coding RNAs that control different physiological processes, have been associated with cancer development, as either oncomiRNAs or tumor-suppressor miRNAs. In the present study we investigated the interaction between ...

Journal: :Journal of immunology 2011
Miaomiao Zhang Qiaofei Liu Siping Mi Xue Liang Zhiqian Zhang Xiaomin Su Jinyi Liu Yingying Chen Mengmeng Wang Yuan Zhang Fenghua Guo Zhujun Zhang Rongcun Yang

Myeloid-derived suppressor cells (MDSCs) were one of the major components of the immune suppressive network. STAT3 has an important role in regulating the suppressive potential of MDSCs. In this study, we found that the expression of STAT3 could be modulated by both miR-17-5p and miR-20a. The transfection of miR-17-5p or miR-20a remarkably reduces the expression of reactive oxygen species and t...

2014
Ajay Palagani Ken Op de Beeck Stefan Naulaerts Jolien Diddens Chandra Sekhar Chirumamilla Guy Van Camp Kris Laukens Karen Heyninck Sarah Gerlo Pieter Mestdagh Joke Vandesompele Wim Vanden Berghe

Glucocorticoids (GCs) selectively trigger cell death in the multiple myeloma cell line MM1S which express NR3C1/Glucocorticoid Receptor (GR) protein, but fail to kill MM1R cells which lack GR protein. Given recent demonstrations of altered microRNA profiles in a diverse range of haematological malignancies and drug resistance, we characterized GC inducible mRNA and microRNA transcription profil...

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