BACKGROUND The formation of the cell wall in Schizosaccharomyces pombe requires the coordinated activity of enzymes involved in the biosynthesis and modification of β-glucans. The β(1,3)-glucan synthase complex synthesizes linear β(1,3)-glucans, which remain unorganized until they are cross-linked to other β(1,3)-glucans and other cell wall components. Transferases of the GH72 family play impor...

Wnt/β-catenin signaling induced by the Norrin/Frizzled-4 pathway has been shown to improve capillary repair following oxygen induced retinopathy (OIR) in the mouse, a model for retinopathy of prematurity. Here we investigated if treatment with the monovalent cation lithium that has been shown to augment Wnt/β-catenin signaling in vitro and in vivo has similar effects. In cultured human microvas...

Previously, we reported that exogenous administration of ghrelin ameliorates glucose metabolism in a neonate streptozotocin (STZ)-induced diabetic rat model through enhancement of β-cell proliferation. However, it was not clear whether the observed β-cell proliferation was a direct or indirect effect (e.g., via orexigenic or growth hormone-stimulated pathways) of ghrelin activity. Here, we aime...

BACKGROUND/OBJECTIVES This study aimed to test the association between APOA5 3'-UTR variants (rs662799) and cardiometabolic traits in Koreans. SUBJECTS/METHODS For this study, epidemiological data, Apolipoprotein A5 (APOA5) genotype information, and lymphoblastoid cell line (LCL) biospecimens from a subset of the Ansung-Ansan cohort within the Korean Genome and Epidemiology study (KoGES-ASAS;...

RATIONALE Induction of the fetal hypertrophic marker gene β-myosin heavy chain (β-MyHC) is a signature feature of pressure overload hypertrophy in rodents. β-MyHC is assumed present in all or most enlarged myocytes. OBJECTIVE To quantify the number and size of myocytes expressing endogenous β-MyHC by a flow cytometry approach. METHODS AND RESULTS Myocytes were isolated from the left ventric...

background sickle hemoglobin is the most common abnormal hemoglobin in the united states. hemoglobin s arises as a result of a single amino acid substitution (glutamic acid to valin at position 6 of the β-globine chain). the presence of fetal hemoglobin (hbf) plays a relatively protective role since a significant amount of hbf interferes with hbs polymerization, the pathogenesis mechanism of th...

background : recurrent aphthous stomatitis (ras) is one of the most common mucosal ulcerative of oral cavity. role of immune system, especially cytokines in immunopathogenesis of aphthous stomatitis was not highly considered. the aim of this study was to evaluate the levels of salivary cytokines, including vegf-r3, tgf-&beta1;, tnf-α, and il-17a/f in patients with ras in two clinical stages, ul...

Thalassemia minor (MT), either β or α, is the most frequent single gene mutation in human beings affecting 6% of population worldwide. It more Mediterranean region, Africa and South-East Asia. On other hand Iron deficiency anemia (IDA), nutritional secondary to gastrointestinal menstrual bleeding, cause acquired anemia. Differentiation between these two types important because both them present...

Objective: Aim was to evaluate the sensitivity and specificity of Mentzer index in differentiating beta thalassemia minor from anemia Iron deficiency. Materials Methods: A cross-sectional study conducted Hematology unit Hayatabad Medical Complex .Sampling done non-consecutively. total 860 cases with value Hemoglobin less than 11 Gm/DL were counted. In all selected full blood count checked Index...

Background & Aim: Family Zingiberaceae is worldwide in   distribution. Plants of the zingiberaceae family are used in traditional   herbal folk medicine besides their uses in spices, cosmetic, ornamental, food   preservatives etc. In Uttarakhand the herbs grow from sub-tropical to   temperate region. Globba sessiliflora Simsrhizomes were collected at maturity stage in ...