Despite increasing recognition of potential untoward interactions between herbal products and conventional medications, a standard system for prospective assessment of these interactions remains elusive. This information gap was addressed by evaluating the drug interaction liability of the model herbal product milk thistle (Silybum marianum) with the CYP3A probe substrate midazolam. The inhibit...

Centaurea benedicta L. is an annual herbaceous plant which belongs to the Asteraceae family. It native Mediterranean region and western Asia commonly known as blessed thistle, holy St Benedict’s thistle or spotted thistle. Traditionally, it has been used treat bubonic plague possesses diuretic, galactagogue, liver-strengthening wound healing properties. Recent research studies have investigated...

milk thistle is used traditionally as a hepaprotective agent and supportive treatment of liver disorders. the most problems in milk thistle harvest are tall height, seed shedding and being spinous. in this trial, effects of 3 native populations (p1: isfahan violet flower, p 2: ahvaz white flower and p3: ahvaz violet flower) and 3 topping levels (t1:control, t2: topping in 7 leaves stage and t3:...

Milk thistle (MT) dietary supplements are widely consumed due to their possible beneficial effect on liver health. As botanicals, they can be contaminated with a variety of fungi and their secondary metabolites, mycotoxins. This study was conducted in an effort to determine the mycological quality of various MT botanical supplements from the US market. Conventional plating methods were used for...

abstract     crop residues are well known for their chemical (allelopathic) effects on crops. the allelopathic potential of the aqueous extracts and chopped residual of sorghum (sorghum bicolor l.) on germination, seedling growth, relative water content, seedling dry weight, seedling length and antioxidant enzyme activity namely catalase (cat), peroxidase (pod) and superoxide dismutase (sod) of...

The use of herbal/botanical products, also referred to as complementary and alternative medicines (CAM), worldwide enjoys increasing popularity. It appears in particular highly prevalent in patient populations already exposed to complex treatment algorithms and polypharmacotherapy, frequently involving narrow therapeutic index drugs. Accordingly, the potential clinical dimension and relevance o...

Silymarin is obtained from the seeds of Silybum marianum (milk thistle), an edible plant that has been used medicinally from ancient times for the treatment of various liver disorders. It is widely prescribed by herbalists and has almost no known side effects. The plant is native to the Mediterranean and grows throughout Europe, North America, India, China, South America, Africa and Australia. ...

Early growth water stress reduces the extract and fresh oil of Silybum marianum L. (S. marianum) shoots. Two experiments were conducted to reduce effects early drought. Treatments in first experiment organic seed cover fillers at three levels (control, vermicompost, peat moss), hydrogel seven 2, 4, 6 g hydrogelF1 per kg OSC, hydrogelA200 cover), deficit (100, 50, 25% field capacity), second exp...