PURPOSE OF REVIEW This article describes current knowledge regarding headache, especially migraine, and includes information on genetics, anatomy, pathophysiology, and pharmacology in order to demonstrate their relevance to clinical phenomenology. RECENT FINDINGS Animal models show that drugs effective in migraine prevention may work by raising the threshold for initiating cortical spreading ...

Several lines of investigation suggest that obsessivecompulsive disorder (OCD) may be associated with serotonergic dysfunction. Researchers have also suggested that serotonin plays an important role in the migraine headache process. However, there are few published reports examining the relation between clinical OCD and migraine headache. Researchers have suggested that the migraine headache sy...

Migraine is a common and debilitating condition. Despite the burden of disease and increasing availability of effective treatment, migraine management is unsatisfactory. Evidence in other chronic conditions indicates that effective physician communication results in better patient understanding and health outcomes.The current literature review was intended to evaluate evidence regarding the rel...

BACKGROUND AND PURPOSE Migraine with aura is a risk factor for ischemic stroke, but the mechanism by which these disorders are associated remains unclear. Both disorders exhibit familial clustering, which may imply a genetic influence on migraine and stroke risk. Genes encoding for endothelial function are promising candidate genes for migraine and stroke susceptibility because of the importanc...

This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of...

Epilepsy and migraine are quite common neurological disorders in the worldwide population characterized by episodic, paroxysmal manifestations. A common etiopathogenetical basis has been hypothesized. Peri-ictal headache is present in the majority of the epileptic patients, however, it may be neglected by the patients themselves as seizures represent the predominant disabling symptom. Comorbidi...

Migraine can be sub-classified not only according to presence of migraine aura (MA) or absence of migraine aura (MO), but also by additional features accompanying migraine attacks, e.g. photophobia, phonophobia, nausea, etc. all of which are formally recognized by the International Classification of Headache Disorders. It remains unclear how aura status and the other migraine features may be re...

Forty patients with migraine who were attending a specialist clinic were interviewed with the Schedule for Affective Disorders and Schizophrenia--Lifetime version. Sixteen (40%) had a history of major depression which was of endogenous type in 15, according to Research Diagnostic Criteria. The tyramine test, a previously established trait marker for endogenous depression, showed that the migrai...

Headache is one of the most common disorders of the nervous system. Headache is further classified into migraine, tension-type headache, and cluster headache. Migraine occurs in about 12% of people age 12 and older in the United States (17% of women and 6% of men). It is about three times more common in women than men. It is estimated that every 10 seconds someone in the United States goes to t...

INTRODUCTION Migraine has a considerable social, economic, physical and emotional burden but remains underdiagnosed and undertreated. A specific migraine screening tool could help remove barriers to health care and be an attractive instrument for epidemiological studies. The objective of this work was to assess the validity of an extended French version of ID Migraine™ as a migraine-screening t...