Until now, the diagnosis of “migraine” is exclusively clinical, and any diagnostic tests are aimed only at excluding other causes of headache [4]. There are also problems with migraine treatment and although both traditional analgesics and specific anti-migraine products are available in the market, treatment of migraine patients is still not sufficiently effective. For example, specific anti-m...

We conducted a postal survey to assess the prevalence and characteristics of neuropathic pain and migraine in a cohort of multiple sclerosis (MS) patients. Of the 1300 questionnaires sent, 673 could be used for statistical analysis. Among the respondents, the overall pain prevalence in the previous month was 79%, with 51% experiencing pain with neuropathic characteristics (NCs) and 46% migraine...

A survey of 148 family doctors attending a continuing medical education migraine update lecture was performed to assess whether family doctors like to treat migraine and other common disorders and the prevalence of migraine. Doctors were asked to respond to the following statement using a five-point Likert scale (from 1, strongly disagree to 5, strongly agree): 'I like to treat patients with th...

Many individuals with migraine who experience an acute migraine headache delay treating that headache because they “wait to see if it’s going to be a migraine.” Unfortunately, by the time the headache builds and blossoms to become full-blown, the treatment they administer is much less likely to be effective. Keep in mind these 2 points: (1) although their specific features may vary, most headac...

Migraine affects mostly women during their reproductive years and is far more prevalent than many people realise. Within 1 year, over 15% of women and 6% of men have attacks of migraine with or without aura.1 Although migraine without aura accounts for the majority of migraine, particularly in women, the overall 1-year prevalence of migraine with aura is around 5% for women and 2% for men.1 Mig...

Although migraine is highly prevalent in children and teenagers, it often goes undetected in these patients, resulting in underdiagnosis and inadequate treatment. Several studies have investigated cognitive changes in adults with migraine. However, there are few studies focusing on children and adolescents. Objective To investigate cognitive performance of adolescents with migraine. Methods...

Migraine has been associated with sleep disturbances. Relationship between sleep quality and migraine frequency is yet to be determined. The present study aimed to investigate sleep disturbances among low-frequency, moderate-frequency, high-frequency, and chronic migraineurs, with and without auras, with well-controlled confounding variables.This cross-sectional controlled study included 357 su...

Migraine has been hypothesized to be a syndrome of chronic low serotonin (5-HT) levels, but investigations of brain 5-HT levels have given equivocal results. Here, we used positron emission tomography (PET) imaging of the 5-HT4 receptor as a proxy for brain 5-HT levels. Given that the 5-HT4 receptor is inversely related to brain 5-HT levels, we hypothesized that between attacks migraine patient...