As-Living-Thing that includes 12 extended metaphors. However, no taxonomies are given for the other very general core metaphors used in MIDAS, which are LocationMetaphor, At-State, Have-State, Container-Metaphor, Kill-Metaphor, and EatingMetaphor. Moreover, there is little discussion of the relationship between these core metaphors. The third question is: is there some way to reduce the enormou...

Colonization of novel habitats is typically challenging to organisms. In the initial stage after colonization, approximation to fitness optima in the new environment can occur by selection acting on standing genetic variation, modification of developmental patterns or phenotypic plasticity. Midas cichlids have recently colonized crater Lake Apoyo from great Lake Nicaragua. The photic environmen...

Growing teratoma syndrome (GTS) is a rare clinical entity first described by Logothetis et al in 1982. Although it is unusual for GTS to be located in the ovary, this report is of a case of an adolescent girl who underwent a complete surgical resection of the mass. Histopathology confirmed only an immature teratoma had originated from the ovary and so she received adjuvant chemotherapy with ble...

background: migraine is one of the most common headaches that affect 11% or more adult population. recently, researchers have designed two questionnaires, namely headache impact test (hit) and migraine disability assessment (midas), with the aim of improving migraine care. these two tests provide a standard measurement about migraine's effects on people's life style that divide patients into 4 ...

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OBJECTIVE To explore the mechanisms of hypospadias induced by in utero exposure to din-butyl phthalate (DBP). METHODS Timed-pregnant Sprague-Dawley rats were administered 750 mg/kg of DBP by gavage from GD (gestation days) 13 to GD 18, whereas control group received corn oil. Genital tubercles (GTs) and blood samples were collected from male fetuses on GD 19. The serum testosterone concentrat...

This study examines for the first time the effects of uninephrectomy (Nx) on modulation of whole kidney glomerular filtration rate (GFR), single-nephron GFR (SNGFR), and progression of diabetic nephropathy in the db/db mouse model of type 2 diabetes mellitus. To characterize SNGFR and tubuloglomerular feedback (TGF) responses to Nx and chronic neuronal nitric oxide synthase inhibition in the db...

Masculinization of external genitalia is an essential process in the formation of the male reproductive system. Prominent characteristics of this masculinization are the organ size and the sexual differentiation of the urethra. Although androgen is a pivotal inducer of the masculinization, the regulatory mechanism under the control of androgen is still unknown. Here, we address this longstandin...

Ž . Ž . Ž The a7-selective agonists 32,4-dimethoxybenzylidene -anabaseine GTS-21 , also known as DMXB, and 34-hydroxy,2-methoxy. Ž . benzylidene anabaseine 4OH-GTS-21 produce a variety of behavioral and cytoprotective effects that may be related to the activation of either large transient currents at high concentrations or small sustained currents at lower agonist concentrations. We are using a...

UNLABELLED Although there only have been a limited number of double-blind, placebo controlled trials, antipsychotics are considered to be effective drugs for the treatment of tics in Gilles de la Tourette syndrome (GTS). Evidence concerning the efficacy of olanzapine and other atypical antipsychotics in the treatment of tics in GTS is growing, but still limited. Little is known about the use of...