Improving methods for high-throughput combinatorial chemistry has emerged as a major area of research because of the importance of rapidly synthesizing large numbers of chemical compounds for drug discovery and other applications. In this investigation, a novel microfluidic chip for performing parallel combinatorial chemical synthesis was developed. Unlike past microfluidic systems designed for...

In the post-genome era, epigenetics has received increasing attentions in recent years. The post-translational modifications (PTMs) of four core histones play central roles in epigenetic regulation of eukaryotic genome by either directly altering the biophysical properties of nucleosomes or by recruiting other effector proteins. In order to study the biological functions and structural mechanis...

an efficient one pot multi component synthesis of 1, 4-polyhydroquinoline derivatives through unsymmetrical hantzsch reaction using lanthanum chloride heptahydrate (lacl3.7h2o) from an aromatic aldehyde, ethyl acetoacetate, dimedone and ammonium acetate as a nitrogen precursor in ethanol at room temperature is described. in the present work we report lanthanum chloride heptahydrate remarkably n...

objective: dendrimers are three-dimensional nanostructures that have numerous applications in medicine, including drug delivery and imaging. although anionic dendrimer polyethylene glycol–citrate has a high potential to increase solubility of water-insoluble drugs and drug delivery, its multi-step synthesis procedure is time consuming. in addition, toxic substances such as dichloromethane are u...

It has been known for some time that the acoustic parameters of vowels and consonants change as a result oftheimmediate segmental environment (ref 1 & 2); and indeed, it has been claimed that an interconsonantal vowel is imposed on and only slightly modifies a continuous movement from the initial to the final consonants (ref 3). Whatever the extent of such coarticulatory effects, it is reasonab...

We present a component for incremental speech synthesis (iSS) and a set of applications that demonstrate its capabilities. This component can be used to increase the responsivity and naturalness of spoken interactive systems. While iSS can show its full strength in systems that generate output incrementally, we also discuss how even otherwise unchanged systems may profit from its capabilities.

Polyglot text-to-speech synthesis, i.e. the synthesis of sentences containing one or more inclusions from other languages, primarily depends on an accurate morphosyntactic analyzer for such mixed-lingual texts. From the output of this analyzer, the pronunciation can be derived by means of phonological transformations which are language-specific and depend on various contexts. In this paper a ne...