BACKGROUND Many studies have evaluated the association between matrix metalloproteinase 9 (MMP9) gene promoter polymorphism and diabetic microvascular complications. However, the results are conflicting and inconclusive. The aim of this meta-analysis was to evaluate the association more precisely. MATERIALS AND METHODS Studies were retrieved from the PubMed, Embase, Medline, China National Kn...

This work presents the design of an expert system that aims to provide the doctors with limited practical experience and the diabetic patients more background for suitable diagnosis of diabetic microvascular complications. In modern society, more and more people get diabetes. This disease affects almost every organ in the body like heart, eyes, kidney, skin, nerves, blood vasculum and foot etc....

Angiogenesis, the formation of new blood vessels from pre-existing vasculature, plays a key role in both physiologic and pathologic events, including wound healing, cancer, and diabetes. Neovascularization has been implicated in the genesis of diverse diabetic complications such as retinopathy, impaired wound healing, neuropathy, and, most recently, diabetic nephropathy. Diabetic nephropathy is...

Glycemic control is the primary mediator of diabetic microvascular complications and also contributes to macrovascular complications. A new study (see related article beginning on page 1049) reveals a previously unrecognized association between oxidant activation of poly(ADP ribose) polymerase (PARP) and upregulation of known mediators of glycemic injury. Inhibitors of PARP may have potential t...

Diabetes is associated with increased risk of cardiovascular disease, coronary heart disease, stroke, acute myocardial infarction, blindness, and renal failure. Strategies to reduce their occurrence are an essential focus of patient care. More than one pathogenic process is involved, and genetics influence the risk. Hyperglycemia is a factor in the development of microvascular and possibly macr...

One hundred insulin-dependent diabetic patients (age < 45 years, 53 smokers) were followed for six years. The age, duration of diabetes and mean glycated haemoglobin levels, were comparable between the smokers and non-smokers. Microvascular complications (retinopathy and increased urine albumin excretion) were commoner and more severe in the smoking group at six years, particularly in heavy smo...

In this review, the authors provide evidences that imply the role of tumor necrosis factor-alpha (TNF-alpha) in the pathogenesis of diabetic complications, especially diabetic polyneuropathy. Under chronic hyperglycemia, endogenous TNF-alpha production is accelerated in microvascular and neural tissues, which may undergo an increased microvascular permeability, hypercoagulability, and nerve dam...

INTRODUCTION Microvascular reactivity is decreased in patients with septic shock; this is associated with worse clinical outcomes. The objectives of the present study were to investigate microvascular reactivity in cardiac surgery patients and to assess any association with clinical outcomes. METHODS We retrospectively analyzed a prospectively collected registry. In total, 254 consecutive adu...

AIMS To estimate remaining life expectancy (RLE), quality-adjusted life expectancy (QALE), causes of death and lifetime cumulative incidence of microvascular/macrovascular complications of diabetes for youths diagnosed with Type 2 diabetes. METHODS A Markov-like computer model simulated the life course for a hypothetical cohort of adolescents/young adults in the USA, aged 15-24 years, newly d...

Diabetes mellitus is a metabolic disease presenting growing prevalence worldwide. Oxidative stress involved in the development of micro- and macrovascular complications diabetic patients. Several pro-oxidative pathways contribute to production reactive oxygen species which can damage different biomolecules variety inflammatory cytokines are also aggravation manifestations. COVID-19 infection en...