We report the case of a Spanish 60-year-old female who presented in 1997 with onychomycosis of the left thumbnail following an injury caused by a fresh fish bone. Microsporum racemosum was repeatedly cultured from nail scrapings, and its identity was confirmed by sequencing the isolate's ITS1/ITS2 and 5.8S rRNA regions. The patient was successfully treated with itraconazole, which was administe...

Keratinolytic proteases secreted by dermatophytes are likely to be virulence-related factors. Microsporum canis, the main agent of dermatophytosis in dogs and cats, causes a zoonosis that is frequently reported. Using Aspergillus fumigatus metalloprotease genomic sequence (MEP) as a probe, three genes (MEP1, MEP2, and MEP3) were isolated from an M. canis genomic library. They presented a quite-...

The recurrent evolutionary emergence of asexual lineages within sexual zoo- and anthropophilic dermatophyte species living in animal-frequented soil is likely to be triggered by changes in ecological niche, i.e., shifts of host animal. Subsequent adaptation to the new host species is noted. Sometimes geographic isolation or intrinsic host factors like human race may also play a role in speciati...

A survey of soil from several sites in Franklin and surrounding counties in central Ohio for human-pathogenic fungi was undertaken. The samples were analyzed for the presence of dermatophytes and keratinophytic fungi by the hair-bait technique, for . systemic mycotic agents by a direct spraying method, and for nocardiae by the paraffinbait technique. The hair-bait technique revealed Trichophyto...

Seven new formamido-diterpenes, cavernenes A-D (1-4), kalihinenes E and F (5-6), and kalihipyran C (7), together with five known compounds (8-12), were isolated from the South China Sea sponge Acanthella cavernosa. Structures were established using IR, HRESIMS, 1D and 2D NMR, and single X-ray diffraction techniques. The isolated compounds were assessed for their cytotoxicity against a small pan...

Out of 410 clinically diagnosed cases of superficial mycoses encountered during 1985 - 87, direct KOH mounts were positive in 250 (62.19%) cases and the cultures were positive in 123 (30.00%) cases. The organisms isolated included Trichophyton rubrum (36.58%). T. simii (32.52%), T.mentagrophytes (12.19%), C.tropicum (8.13%), Microsporum gypseum (6.50%), Epidermophyton floccossum (2.43%), T. vio...

background: subtilisin -like proteases are the group of proteases including keratinases found in dermatophytes which de­graded keratin. determination of the proteases activity of trichophyton vanbreuseghemii isolates which were obtained from soil and clinical and soil isolates of microsporum gypseum in iran and characterization of their genome were aim of present study. methods: ezymatic activi...

A method of treatment of tinea capitis is presented in a case of a 10-year-old boy who was referred to the pediatric surgical unit for the treatment of a skin lesion on the scalp, which had persisted for more than two months. The initial dermatologic examination led to the clinical diagnosis of inflammation of the scalp, while mycological analysis revealed an uncommon dermatophyte agent, Micros...

In recent times increasing occurrence of dermatophytosis, especially among the school children in eastern India was evidenced along with increased tendency of keeping companion animals such as dogs and cats. This study was undertaken to detect the occurrence of dermatophytes with antifungal susceptibility among the companion animals. A total of 1501 healthy companion animals comprising 1209 dog...

The keratinolytic potential of the kearatinolytic fungi was determined by the release of protein by utilizing feather keratin. The total protein yield was found to be 430 ug mL -1 from Chrysosporium indicum, 410 ug mL -1 protein from Microsporum canis, 390 ug mL -1 protein from Crysosporium keratinophillum, 370 ug mL -1 protein from Microsporum gypseum, 360 ug mL -1 protein from Trichophyton ru...