MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent Studies opened the way for the use of circulating miRNAs as non-invasive diagn...

Background: Gastric cancer (GC) is one of the most prevalent cancers with a high rate of mortality in the world. In recent years, microRNAs (miRNAs) have been proposed to be involved in GC development. In this study, we aimed at investigating differential expression level of miR-155-5p, miR-15a, miR-15b, and miR-186 in GC. Methods: For this research, we used qPCR to investigate miR-15b, miR-155...

Objective: We hypothesized that microRNAs (miRNAs) might be involved in tumor development by critically regulating cancer stem cell (CSC) markers the early stages of colon (eCC). This study aimed to determine expression profiles miRNAs CSC-positive eCC patients and examine their associations with recurrence. Materials Methods: analyzed CD133, LGR5 SOX2 CSC status 30 specimens. Then, using resul...

Stem rot, caused by soilborne pathogen Sclerotium rolfsii, is one of the most destructive diseases peanut (Arachis hypogaea L.) worldwide. Although microRNAs (miRNAs) are indispensable regulators for plant defense, miRNA species have not been explored immunity against rolfsii. Here, we report a comparative analysis durably resistant variety Rizhaohua-1 (Rzh) and susceptible Jitian-1 (JT) in res...

MicroRNAs (miRNAs) are a group of small, noncoding RNAs that act as novel regulators of gene expression through the post-transcriptional repression of their target mRNAs. miRNAs have been implicated in diverse biologic processes, and it is estimated that up to half of all transcripts are regulated by miRNAs. Recent studies also demonstrate a critical role for miRNAs in renal development, physio...

MicroRNAs (miRNAs) pleiotropically modulate gene expression in all cell types. Many miRNAs are overexpressed in tumors, and recent findings suggest that tumors can be 'addicted' to miRNA overexpression, yielding a possible therapeutic opportunity.

MicroRNAs (miRNAs) are small, conserved RNAs known to regulate several biological processes by influencing gene expression in eukaryotes. The implication of miRNAs as another player of regulatory layers during heart development and diseases has recently been explored. However, there is no study which elucidates the profiling of miRNAs during development of heart till date. Very limited miRNAs h...

The discovery of microRNAs has been a path-breaking step in understanding the full scope of post-transcriptional gene regulation. The microRNAs (miRNAs) are highly conserved, non-coding short ribonucleic acid (RNA) molecules, approximately 22 nucleotides long[6] and are found in all eukaryotic cells, except fungi and marine plants. MicroRNAs (miRNAs) post-transcriptionally regulate the expressi...

Ginkgo biloba leaves contain abundant flavonoids, and flavonoid accumulation is affected by age. MicroRNAs (miRNAs) play an important role in the plant aging pathway. However, miRNAs involved biosynthesis related to age G. have rarely been studied. In this study, we compared 1-, 4-, 7-year-old ginkgo seedings found a significant decrease content of quercetin, kaempferol, total flavonol aglycone...