BACKGROUND It is controversial whether microRNA-126 is a tumor suppressive or oncogenic miRNA. More experiments are needed to determine whether microRNA-126 is associated with non-small cell lung cancer risk and prognosis. METHODS Over-expression of microRNA-126 was performed to evaluate the cell invasion and tumor growth in non-small cell lung cancer (NSCLC) cell lines and nude mouse xenogra...

To explore the effect of circular RNA_0025033 on proliferation, migration and invasion cervical cancer HeLa cells its molecular mechanism. The tissues adjacent 39 patients with in our hospital from January 2017 to December 2020 were selected. expression levels microRNA-1256 detected by Quantitative reverse transcription polymerase chain reaction. Cell counting kit 8 was used detect cell viabili...

To investigate the influence of harpagide isolated from Scrophularia ningpoensis Hemsl. on human umbilical vascular endothelial cells damage induced by oxidized low-density lipoprotein and its possible mechanism. Human were cultured in vitro. Different doses (20, 40, 80 μmol/l) applied to treat lipoprotein, overexpressing microRNA-140-5p μg/ml was with downregulation. Enzyme-linked immunosorben...

The FermaT transformation system, based on research carried out over the last sixteen years at Durham University, De Montfort University and Software Migrations Ltd., is an industrial-strength formal transformation engine with many applications in program comprehension and language migration. This paper is a case study which uses automated plus manually-directed transformations and abstractions...

The interpretive-execution facility of Enterprise Systems Architecture/390TM (ESA/390TM) provides an instruction for the execution of virtual machines. This instruction, called START INTERPRETIVE EXECUTION (SIE), was initially created for virtualizing either System/370m or 370-XA architectures and was used later for virtualizing ESA/370' and ESA/390 architectures. SIE has evolved to provide cap...

The Enterprise Systems Architecturel370" provides a significant step in the IBM System/370 evolution by providing new capabilities for virtual addressing and program linkage across multiple address spaces. This paper reviews the evolution that led to this advance and illuminates the goals, such as eliminating growth constraints and improving security, integrity, reliability, and performance, th...

Computer softwares for processing Thai language are developed at National Museum of Ethnology,Osaka,Japan. We use a popular intelligent terminal TEKTRONIX 4051 for inputting and editing,IBM 370 model 138 for KWIC making and sorting, and CANON's laser beam printer for final output. Using these systems,"Kotmai Tra Sam Duang"(the Three Seals Law)which contains many kind of laws and ordinances proc...

Forkhead box protein O1 (FOXO1), a key member of the FOXO family of transcription factors, acts as a tumor suppressor and has been associated with various key cellular functions, including cell growth, differentiation, apoptosis and angiogenesis. Therefore, it is puzzling why FOXO protein expression is downregulated in cancer cells. MicroRNAs, non-coding 20~22 nucleotide single-stranded RNAs, r...

Mammalian hibernation involves re-programming of metabolic functions, in part, facilitated by microRNA. Although much is known about microRNA function, we lack knowledge on low temperature microRNA target selection. It is possible that the thermodynamics of microRNA target selection could dictate unique temperature-dependent sets of microRNA targets for hibernators.