نتایج جستجو برای: microrna ها

تعداد نتایج: 378343  

2014
Zhili Wen Wei Huang Yuliang Feng Wenfeng Cai Yuhua Wang Xiaohong Wang Jialiang Liang Mashhood Wani Jing Chen Pin Zhu Ji-Mei Chen Ronald W. Millard Guo-Chang Fan Yigang Wang Yao Liang Tang

MicroRNAs have been appreciated in various cellular functions, including the regulation of angiogenesis. Mesenchymal-stem-cells (MSCs) transplanted to the MI heart improve cardiac function through paracrine-mediated angiogenesis. However, whether microRNAs regulate MSC induced angiogenesis remains to be clarified. Using microRNA microarray analysis, we identified a microRNA expression profile i...

Journal: :archives of medical laboratory sciences 0
mohammad ebrahimifard professor; department of virology, tarbiat modares university, tehran, iran mahshid zandi abdolvahab moradi

background: microrna is a type of small rna of about 22 nucleotide length. most popular mirnas are found in the liver and are extensively important in determining the biological and clinical functions. microrna, in host cells, may impact the replication of viruses either positively or negatively. in this study the mir-122 expression was examined and compared in three groups, two sample groups o...

Journal: :middle east journal of cancer 0
ale eba department of biochemistry, era’s lucknow medical college and hospital, lucknow, india syed tasleem raza department of biochemistry, era’s lucknow medical college and hospital, lucknow, india saliha rizvi department of biochemistry, era’s lucknow medical college and hospital, lucknow, india farzana mahdi department of biochemistry, era’s lucknow medical college and hospital, lucknow, india

micrornas are tiny, 18-25 nucleotides in length, non-coding rna molecules preserved throughout evolution. these molecules primarily control gene expression at the post-transcriptional and transcriptional levels. micrornas control target gene expression by a phenomenon known as rna interference. rna interference based therapeutics that utilize target gene silencing/degradation by specific micror...

RNA processing is essential factor for synthesis of functional and structural proteins in eukaryote cells. In eukaryote organisms it will be initiated with transcription of DNA in nucleolus and terminated to mRNA translation in cytoplasm, finally mRNA degraded. Protein synthesis followed as different steps, includes 5' capping, poly adenylating, processing and transferring from nucleolus to cyt...

2015
Sishuo Wang Keith L. Adams

Gene duplication provides large numbers of new genes that can lead to the evolution of new functions. Duplicated genes can diverge by changes in sequences, expression patterns, and functions. MicroRNAs play an important role in the regulation of gene expression in many eukaryotes. After duplication, two paralogs may diverge in their microRNA binding sites, which might impact their expression an...

Journal: :Cancer prevention research 2013
Ajay Bansal Vijayalaxmi Gupta Kenneth Wang

The rapid increase and poor survival of esophageal adenocarcinoma (EAC) have led to significant efforts to promote early detection. Given that the premalignant lesion of Barrett's esophagus (BE) is the major known risk factor for EAC, multiple investigators have studied biomarker signatures that can predict malignant progression of BE to EAC. MicroRNAs, a novel class of gene regulators, are sma...

2016
Jianwei Tian Liping Hu Xiao Li Jian Geng Meng Dai Xiaoyan Bai

BACKGROUND The prognosis of non-small-cell lung cancer (NSCLC) is poor yet mechanistic understanding and therapeutic options remain limited. We investigated the biological and clinical significance of microRNA-130b and its relationship with apoptosis in NSCLC. METHODS The level of microRNA-130b in relationship with the expression of PPARγ, VEGF-A, BCL-2 and apoptosis were analyzed in 91 lung ...

Journal: :Genetics and molecular research : GMR 2009
Hao-Yue Fu Ding-Yu Xue Xiang-de Zhang Pei-Ying Yang

At present, studies on microRNA mainly focus on the identification of microRNA genes and their mRNA targets. Although researchers have identified many microRNA genes, relatively few microRNA targets have been identified by experimental methods. Computational programs designed for predicting potential microRNA targets provide numerous targets for experimental validation. We used a Markov model t...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2013
Qiang Huang Lei Liu Chen-Hai Liu Hao You Feng Shao Fang Xie Xian-Sheng Lin San-Yuan Hu Chuan-Hai Zhang

BACKGROUND MicroRNAs are noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was to determine the role of microRNA-21 in cholangiocarcinomas and its relationship to cholangiocarcinoma RBE cell capacity for invasion and metastasis. METHODS MicroRNA-21 expression was investigated in 41 cases of cholangiocarcinoma samples by in situ hybridization an...

2014
Ding-Zuan Zhang Kin-Mang Lau Eddie S. Y. Chan Gang Wang Cheuk-Chun Szeto Kenneth Wong Richard K. W. Choy Chi-Fai Ng

BACKGROUND Evidence implicated the diagnostic significance of microRNAs in whole urine/urine sediments in urothelial carcinoma of the bladder (UCB). However, the contaminated blood cells in patients with haematouria significantly altered the expression profiles of urinary microRNA, influencing the test accuracy. METHODS MicroRNA profiles of the urine supernatants of UCB patients and controls ...

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