Piroxicam is a poorly soluble, highly permeable drug and is characterized by a slow and gradual absorption via the oral route and this causes a delayed onset of therapeutic effect. Thus, plain piroxicam preparations are not indicated for analgesia. The results of the in vivo study revealed that the GL dosage form would be advantageous with regards to rapid onset of action, especially in various...

Electrostatic separation of granular plastics mixtures has become a wellestablished technology, with industrial applications in the area of waste electric and electronic equipment (WEEE) recycling. The aim of this work is to validate the feasibility of selectively sorting of micronized waste plastics in a two-rotating-disks-type tribo-aero-electrostatic separator. The experiments are carried ou...

OBJECTIVE To review the efficacy and safety of fenofibrate in the management of hyperlipidemias. DATA SOURCES A MEDLINE search (1974-October 1998), Current Contents search, additional references from article bibliographies, and the package insert from the manufacturer were used to identify data for evaluation. Studies evaluating fenofibrate (peer-reviewed publications, package insert data) we...

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4.1 Absorption, distribution, metabolism and excretion 4.1.1 Humans The pharmacokinetics of the newer progestogens, desogestrel, norgestimate and gestodene, has been reviewed (Fotherby, 1996). There are only a few reports of studies on the disposition of these progestogens, mostly in combination with ethinyloestradiol, and these are discussed in detail in the monograph on 'Oral contraceptives, ...

A new anti-diarrheic drug for humans has been developed based on the physical and chemical properties of the purified natural clinoptilolite NZ. A series of physical, chemical, technological, pharmacological, microbiological, and clinical studies were successfully conducted to meet the requirements of the Cuban Drug Quality Agency. The most important results concerning the properties and biolog...