Tumor vessel co-option is a crucial predictor for tumor invasiveness but easy to ignore in vascular targeting therapy. A high density of located alongside the frontier predicted tendency invasion and regional metastasis. Herein, novel second near-infrared (NIR-II) nanoagent (Coi8DFIC-sorafenib nanoparticles, CS NPs [CS NPs]) was constructed with an organic Coi8DFIC dye sorafenib, which demonstr...