mhc class i

نتایج جستجو برای: mhc class i

تعداد نتایج: 1385931 فیلتر نتایج به سال:

Major histocompatibility complex class I molecule serves as a ligand for presentation of the superantigen staphylococcal enterotoxin B to T cells.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1996

A C Häffner K Zepter C A Elmets

Superantigens, such as staphylococcal enterotoxin B (SEB), elicit a strong proliferative response in T cells when presented in the context of major histocompatibility complex (MHC) class II molecules. We observed a similar T-cell response, when MHC class II-negative epidermal cell lines were employed as antigen-presenting cells. Immunoprecipitation studies indicated that the ligand to which SEB...

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Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages.

Journal: :Journal of immunology 2002

Yuko Ohta E Churchill McKinney Michael F Criscitiello Martin F Flajnik

Cartilaginous fish (e.g., sharks) are derived from the oldest vertebrate ancestor having an adaptive immune system, and thus are key models for examining MHC evolution. Previously, family studies in two shark species showed that classical class I (UAA) and class II genes are genetically linked. In this study, we show that proteasome genes LMP2 and LMP7, shark-specific LMP7-like, and the TAP1/2 ...

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MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment

Journal: :Journal of Experimental Medicine 2010

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Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells.

Journal: :Journal of virology 2002

Armin Rehm Arne Engelsberg Domenico Tortorella Ida J Körner Insa Lehmann Hidde L Ploegh Uta E Höpken

Human cytomegalovirus (HCMV) encodes several proteins that inhibit major histocompatibility complex (MHC) class I-dependent antigen presentation. The HCMV products US2 and US11 are each sufficient for causing the dislocation of human and murine MHC class I heavy chains from the lumen of the endoplasmic reticulum to the cytosol, where the heavy chains are readily degraded. The apparent redundanc...

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Antigen storage compartments in mature dendritic cells facilitate prolonged cytotoxic T lymphocyte cross-priming capacity.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2009

Nadine van Montfoort Marcel G Camps Selina Khan Dmitri V Filippov Jimmy J Weterings Janice M Griffith Hans J Geuze Thorbald van Hall J Sjef Verbeek Cornelis J Melief Ferry Ossendorp

Dendritic cells (DCs) are crucial for priming of naive CD8(+) T lymphocytes to exogenous antigens, so-called "cross-priming." We report that exogenous protein antigen can be conserved for several days in mature DCs, coinciding with strong cytotoxic T lymphocyte cross-priming potency in vivo. After MHC class I peptide elution, protein antigen-derived peptide presentation is efficiently restored,...

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TAP-Independent MHC Class I Peptide Antigen

1998

Yan Shi Kelly D. Smith Charles T. Lutz

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Trafficking of spontaneously endocytosed MHC proteins.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1999

I Chiu D M Davis J L Strominger

Class I MHC protein primarily presents endogenous antigen but also may present exogenous antigen. Here, we investigated the intracellular pathway of spontaneously internalized class I MHC protein by confocal microscopy. beta(2)-microglobulin (beta(2)m), labeled with a single fluorophore, was exchanged at the surface of B cell transfectants to specifically mark cell surface and endocytosed class...

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Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression.

Journal: :Journal of virology 2000

D T Evans P Jing T M Allen D H O'Connor H Horton J E Venham M Piekarczyk J Dzuris M Dykhuzen J Mitchen R A Rudersdorf C D Pauza A Sette R E Bontrop R DeMars D I Watkins

Simian immunodeficiency virus (SIV) infection of the rhesus macaque is currently the best animal model for AIDS vaccine development. One limitation of this model, however, has been the small number of cytotoxic T-lymphocyte (CTL) epitopes and restricting major histocompatibility complex (MHC) class I molecules available for investigating virus-specific CTL responses. To identify new MHC class I...

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Different MHC Class I Heavy Chains

2004

Keith G. Gould Sophie Tourdot Mohamed Nejmeddine Simon J. Powis

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A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002

Masanori Kasahara Yutaka Watanabe Motoko Sumasu Taeko Nagata

Some members of the major histocompatibility complex (MHC) class I gene family are encoded outside the MHC. Here we describe a family of mouse class I-like genes mapping to the vicinity of the leukocyte receptor complex (LRC) on chromosome 7. This family, which we call Mill (MHC class I-like located near the LRC), has two members designated Mill1 and Mill2. Both genes are predicted to encode me...

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