OBJECTIVE To validate a back-specific instrument for functional assessment in the young athlete for clinical and research purposes, the Micheli Functional Scale (MFS). DESIGN Prospective cohort study, Diagnostic Level II. SETTING Division of Sports Medicine Clinic, Children's Hospital Boston. PARTICIPANTS Male and female patients aged 12 to 22 with and without low back pain. INTERVENTIO...

Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with skeletal involvement. It is caused by mutations in fibrillin1 (FBN1) gene resulting in activation of TGF-β, which developmentally regulates bone mass and matrix properties. There is no consensus regarding bone mineralization in children with MFS. Using dual-energy X-ray absorptiometry (DXA), we evaluated bone mineral...

This study investigated that the spinal MFs can create compressive follower loads (CFLs) in the lumbar spine in a dynamic state. Three-dimensional optimization and finite element (FE) models of the spinal system were developed and validated using reported experimental data. An optimization analysis was performed to determine the MFs that create CFLs in the lumbar spine in various sagittal postu...

In the communist camp during Cold War, exercising power was a male domain. The Ministry of State Security (MfS) former German Democratic Republic (GDR) no exception. Within organization, women were employed but they rarely made career. bottom hierarchy agents. This article examines who agents in rank MfS. Based on statistical materials, it gives an overview women’s role and character their cove...

BACKGROUND Marfan syndrome (MFS) is an autosomal, dominantly inherited, connective tissue disorder usually caused by a mutation in the fibrillin-1 gene (FBN1). As fibrillin-1 is a component of the extracellular matrix of the myocardium, mutations in FBN1 may cause impairment of ventricular function. Furthermore, aortic elasticity is decreased in patients with MFS, which might also impair ventri...

BACKGROUND Cardiovascular complications are the leading cause of mortality and morbidity in Marfan syndrome (MFS), a dominantly inherited disorder caused by mutations in the gene that encodes fibrillin-1. There are approximately 18,000 patients in the UK with MFS. Current treatment includes careful follow-up, beta blockers, and prophylactic surgical intervention; however, there is no known trea...

AIMS Subclinical diastolic dysfuntion in patients with preclinical heart failure with preserved ejection fraction (HFpEF) has been demonstrated in patients with Marfan syndrome (MFS). We investigated the relationship between diastolic dysfunction and NT-proBNP levels in patients with MFS. METHODS AND RESULTS NT-proBNP, C-reactive protein (CRP) and diastolic function were assessed in 217 patie...

Background: A rare clinical variant of Guillain-Barre syndrome, known as Miller Fisher syndrome (MFS), is an immunemediated neuropathy classically characterized by a triad consisting of ophthalmoplegia, ataxia, and areflexia.1,2 Although MFS is thought to be a disease of immunological basis, other pathological entities may give rise to the syndrome as well. The diagnosis of MFS relies upon clin...

Animal studies have shown that electromagnetic field exposure may interfere with the activity of brain cells, thereby generating behavioral and cognitive disturbances. However, the underlying mechanisms and possible preventions are still unknown. In this study, we used a mouse model to examine the effects of exposure to extremely low-frequency (50 Hz) electromagnetic fields (ELF MFs) on a recog...

AIMS Previous studies provided evidence about left ventricular systolic and diastolic dysfunction in adults with Marfan syndrome (MFS). However, in the literature, data on right ventricular and bi-atrial diastolic function are limited. We aimed to investigate whether, in the absence of significant valvular disease, diastolic dysfunction is present not only in both ventricles but also in the atr...