Case presentation: Female adolescent, 15 years old, complains that for 6 months she has felt generalized muscle weakness and increased in recent days associated with changes sensitivity left dimidium, evolving 1 week to the right ~15 after, culminates bilaterally lower limb plegia. She denies fever use of medication continuous use. Her relevant personal history is: tested positive SARS-CoV-2 be...

BACKGROUND Establishment of laparoscopic cholecystectomy as an outpatient procedure has accentuated the clinical importance of reducing early postoperative pain, as well as postoperative nausea and vomiting (PONV). We therefore planned to evaluate the role of a multimodal approach in attenuating these problems. METHODS One hundred and twenty adult patients of ASA physical status I and II and ...

In the fall of 2012, as we finalized this issue of , an unprecedented outbreak of fungal meningitis occurred that was caused by contaminated preservative-free methylprednisolone acetate solution from the New England Compounding Center used in epidural steroid injections in thousands of patients. The predominant pathogen was found to be Exserohilum rostratum (a black mold). Aspergillus fumigatus...

PURPOSE We aimed to test our primary hypothesis that the effects of methylprednisolone on bone marrow in chickens are age-sensitive and increase with prolonged treatment and our secondary hypothesis that the effects of methylprednisolone on bone marrow can have individual effects. METHODS Sixteen control (group A) and 29 methylprednisolone-treated (group B) chickens were categorised by age: p...

Methylprednisolone is a commonly used drug for the treatment of spinal cord injury, but high doses of methylprednisolone can increase the incidence of infectious diseases. Methotrexate has anti-inflammatory activity and immunosuppressive effects, and can reduce inflammation after spinal cord injury. To analyze gene expression changes and the molecular mechanism of methotrexate combined with met...