The acetaldehyde-xanthine oxidase system in the presence and absence of myeloperoxidase (MPO) and chloride has been employed as a model of the oxygen-dependent antimicrobial systems of the PMN. The unsupplemented xanthine oxidase system was bactericidal at relatively high acetaldehyde concentrations. The bactericidal activity was inhibited by superoxide dismutase (SOD), catalase, the hydroxyl r...

the glass transition temperature of several pvac(1)-b-poly(ma-co-mma) (2) terpolymers with different fractions of methyl acrylate (ma) and methyl methacrylate (mma) repeating units in random copolymer (block 2) were calculated with barton, kwei and topological equations. the calculation was on the basis of the correlation between the fraction of repeating units in random copolymers and theoreti...

Xanthine phosphoribosyltransferase (XPRT) and hypoxanthine-guanine (HGPRT) are purine salvaging enzymes of Leishmania donovani with distinct 6-oxopurine specificities. LdXPRT phosphoribosylates xanthine, hypoxanthine, guanine, preference toward whereas LdHGPRT only hypoxanthine guanine. In our study, was used as a model to understand these base Mutating I209 V, the conserved residue found in HG...

Objective(s) PDE3 has a functional role in insulin secretion and action. We investigated the metabolic effects of new synthetic PDE3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. Materials and Methods The test compound or solvent was injected subcutaneously to mice, for 7 days. On day 8, blood and liver samples were obtained. In hyperglycemic rat, 0.5 g/kg glucose with o...

Alcaligenes jaecalis is capable of growing in response to simple pteridines as the sole source of nitrogen (1). Simple pteridines appear to be metabolized in this organism through the common intermediate, tetraoxypteridine (1, 2)) and cell-free extracts of the organism catalyze the conversion of tetraoxypteridine to xanthine-8-carboxylic acid (1). In these conversions the nitrogen atoms of the ...

Myocardial xanthine oxidase has been associated with reoxygenation injury induced by oxygen radicals. The damage due to myocardial ischemia and reperfusion increases with age; therefore, one would expect to find more xanthine oxidase in adult than in young hearts. Consequently, we studied the age-dependence of xanthine oxidoreductase activity in hearts, in addition to the localization of the en...

In the liver tissue of newborn mice, xanthine oxidase activity is very low during the first 7 to 14 days of life. Infection of mice with several different viruses prematurely induced xanthine oxidase activity 2- to 10-fold in the liver tissue. Generally, overt signs of illness appeared after xanthine oxidase induction; however, some viruses induced the enzyme activity without causing morbidity ...