Objective: To investigate the effect of the methanolic extract of Hibiscus rosa sinensis roots (H. sinensis) on the central nervous system in mice and rats. Materials and methods: The methanolic extract of H. sinensis was studied on pentobarbital-induced sleeping time, elevated plus maze, hole board test, foot shock-induced aggression, haloperidol-induced catalepsy, lithium-induced head twitche...

Atherosclerosis is one of the risk factors for coronary artery disease. The present study highlights the antiatherosclerotic activity of Methanolic extract of polyherbal preparation in experimentally induced atherosclerotic rats. Atherosclerosis was developed in male Albino Wistar rats, which were randomly divided into five groups of six animals each; by feeding with high cholesterol diet for 2...

Chemical fractionation of the methanolic extract of leaves of Leiothrix spiralis Ruhland afforded the flavonoids luteolin-6-C-β-D-glucopyranoside (1), 7-methoxyluteolin-6-C-β-D-glucopyranoside (2), 7-methoxyluteolin-8-C-β-D-glucopyranoside (3), 4'-methoxyluteolin-6-C-β-D-glucopyranoside (4), and 6-hydroxy-7-methoxyluteolin (5), and the xanthones 8-carboxymethyl-1,5,6-trihydroxy-3-methoxyxanthon...

The investigation was conducted with methanolic fruit extract of Averrhoa carambola for its antibacterial and cytotoxic activities. Antibacterial activity of the extract was evaluated against various Gram-positive and Gram-negative bacteria using disk diffusion technique. For cytotoxic activity, brine shrimp lethality bioassay was performed to estimate LC50 values. In our preliminary screening,...

BACKGROUND Melastoma malabathricum (MM) Linn leaves traditionally use in the treatment of diabetic conditions. The aim of the present investigation was to evaluate the antioxidant, antihyperlipidemic and antidiabetic activity of methanolic extract taken from Melastoma malabathricum Linn (Melastomaceae). METHODS The methanolic leaves extract of MM Linn leaves used for the study. Chemical test ...

Some medicinal plants are used traditionally in Saudi Arabia to treat many bacterial infections. Three plants, lemongrass (Oymbopogon citrates), lantana (Lantana camara), and wild olive leaves (Olea europaea) were collected, identified, extracted with either hot water or organic solvents (methanol, diethyl ether, ethyl acetate and n-butanol) to investigate their antibacterial activities against...

The antibacterial activity of Citrus karna fruit peel extracts was evaluated on bacteria strains like Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Hexane, chloroform and methanol were used for extraction and the antibacterial activity was performed by agar well diffusion method. The results were compared with ampicillin, a commercial antibacterial agent...

Objective: The aim of this study was to investigate CYP1A interaction of crude extracts (ethanolic, methanolic, hydromethanolic & aqueous) of Withania somnifera and its principal phytoconstituents (withaferin-A and withanolide-A) in rat and human liver microsomes. Methods: In vitro study were carried out in both rat & human liver microsomes while, in vivo CYP1A interaction potential was investi...

Aim of the study was to investigate the methanol and aqueous extracts of heartwood of C. sappan for its hepatoprotective activity against CCl4 induced toxicity in freshly isolated rat hepatocytes and animals. Freshly isolated rat hepatocytes were exposed to CCl4 (1%) along with/without various concentrations of methanolic and aqueous extract of C. sappan (1000-800 microg/ml) and the levels of s...

Screening of antibacterial and antitumour activities of 33 different extracts prepared with three types of solvents (water, ethanol and methanol) was conducted. The extracts were obtained from 11 different plant species grown in Turkey: Eryngium campestre L., Alchemilla mollis (Buser) Rothm., Dorycnium pentaphyllum Scop., Coronilla varia L., Onobrychis oxyodonta Boiss., Fritillaria pontica Wahl...