introduction: mucoepidermoid carcinoma represents one of the most common malignant salivary gland tumors.however, the sclerosing morphologic variant is extremely rare with only 23 reported cases in the english-language literature since it was discovered in 1987. case report: herein, we describe another case that was diagnosed in a 25-year-old woman presenting with a posterior auricular mass, as...

CONTEXT Distinction between primary lung carcinomas and metastases from other sites, especially the urinary tract, is a common diagnostic dilemma. As urothelial carcinomas can demonstrate a broad range of morphology and frequently demonstrate squamous differentiation, discerning metastatic urothelial carcinoma to the lung from primary pulmonary squamous cell carcinoma can be challenging. OBJE...

For decades, the selection of chemotherapeutic regimens for the treatment of recurrent or metastatic nasopharyngeal carcinoma has been mainly empirical. To our knowledge, there is no phase 3 trial that has been conducted to determine the optimal treatment for these patients before our publication. Recently, we published an article in The Lancet entitled "Gemcitabine plus cisplatin versus fluoro...

Primary and acquired resistance to anti-epidermal growth factor receptor (EGFR) drugs are clinically relevant problems in patients with metastatic colorectal carcinoma. A complex network of molecular alterations is involved in this phenomenon. Bertotti et al. report the development of serially transplantable groups of tumor xenografts in immune-deficient mice from patient-derived, genetically c...

Actas Dermosifiliogr. 2008;99:157-69 159 subcutaneous tissue simulating celullitis. N Engl J Med. 1950:242: 779-81. 5.Ruiz de Erenchun FR, Vázquez Doval J, Valérdiz S, Serna MJ, Quintanilla E. Inflammatory metastatic carcinoma: a clinical and histopathologic study of three cases. J Dermatol Surg Oncol. 1991; 17:784-7. 6.Tan BB, Marsden JR, Sanders DSA. Melanoma erysipeloides: inflammatory metas...

Metastatic renal cell carcinoma is potentially a lethal disease with in some cases aggressive behavior. The given fact that the patterns of metastases from RCC are not clearly identified, which may involve some rare metastatic locations. We present a case of 58 years old male presented with painless left scrotal mass, which was discovered to be an intrascrotal metastases appeared 3 years after ...

BACKGROUND Alterations in hedgehog signaling are implicated in the pathogenesis of basal-cell carcinoma. Although most basal-cell carcinomas are treated surgically, no effective therapy exists for locally advanced or metastatic basal-cell carcinoma. A phase 1 study of vismodegib (GDC-0449), a first-in-class, small-molecule inhibitor of the hedgehog pathway, showed a 58% response rate among pati...

Background: Solid organ transplant recipients develop cutaneous malignancies at a higher rate and with a more aggressive clinical course when compared to the general population. Due to a lack of current information within the transplant literature, we sought to assess the clinical course, treatment and outcomes of metastatic skin cancer in solid organ transplant recipients. Methods: Medical rec...

ba c k g r o u nd: skin  metastases occur  in  1-5%  of  solid  tumors  and  are  rarely the presenting sign of internal malignancies. certain features in skin lesions raise suspicion of metastasis from solid tumors. c a s e presentation: in this article a 61-year-old woman is presented with erythematous skin nodules  in  upper  abdomen  and  chest. histopathological evaluation  of  lesions sug...

Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of the stomach secondary to lung carcinoma were diagnosed by gastroscopy. The first...