introduction: metabolic syndrome includes obesity, hypertriglyceridemia, glucose intolerance, hypertension and lipid profile abnormalities. the risk of cardiovascular diseases with this syndrome is higher than every components alone. in view of its burden and high mortality rate, this syndrome should be noted. methods: the 25-64 aged individuals in 17th zone of tehran were studied. it was desig...

The normal function of the human myocardium requires the proper generation and utilization of energy and relies on a series of complex metabolic processes to achieve this normal function. When metabolic processes fail to work properly or effectively, heart muscle dysfunction can occur with or without accompanying functional abnormalities of other organ systems, particularly skeletal muscle. The...

Tissues are composed of diverse cell subpopulations each with distinct metabolic characteristics that influence overall behavior. Unfortunately, traditional histopathology imaging techniques are 'blind' to the spatially ordered metabolic dynamics within tissue. While mass spectrometry imaging enables spatial mapping of molecular composition, resulting images are only a static snapshot in time o...

Introduction The recent development of a technique to enhance C NMR polarizations by ≥10,000x may allow us to follow metabolic processes non-invasively with unprecedented sensitivity and temporal resolution [1]. The importance of such development for in vivo metabolic imaging is clear and many important works have been done showing the utility of hyperpolarized metabolic imaging both in cancer ...

The pancreas plays a crucial, fundamental role in the endocrinological control of numerous metabolic processes. purpose this study was to find out how improve care patients with pancreatic pathology

Inherited single-gene disorders offer unique insights into the role of metabolic processes in arrhythmogenesis. Although many metabolic defects result in cardiomyopathy as a physiologic compensation, it is clear that specific perturbations are associated with particular arrhythmias. Metabolic gene defects may cause arrhythmia through many different pathways, including developmental effects on c...

Extracellular cues affect signaling, metabolic, and regulatory processes to elicit cellular responses. Although intracellular signaling, metabolic, and regulatory networks are highly integrated, previous analyses have largely focused on independent processes (e.g., metabolism) without considering the interplay that exists among them. However, there is evidence that many diseases arise from mult...

Therapeutic interventions can only be effective when administered during their specific " therapeutic window. " A multitude of clinical trials based on highly successful preclinical studies performed mostly in rodents have failed to translate into similarly successful clinical outcomes (1–4). One potentially important but largely ignored factor contributing to these fiascoes is the different bi...

Background: In severe chronic obstructive pulmonary disease (COPD), interval training (IT) can be performed with oxygen support, which provides beneficial effect on metabolic processes, tissue perfusion, and peripheral muscle function.

BACKGROUND Different studies have shown that cellular enzymatic activities are able to self-organize spontaneously, forming a metabolic core of reactive processes that remain active under different growth conditions while the rest of the molecular catalytic reactions exhibit structural plasticity. This global cellular metabolic structure appears to be an intrinsic characteristic common to all c...