The glutathione S-transferases (GSTs) are a family of multifunctional enzymes involved in cellular detoxification. The aim of this study was to evaluate the effect of albendazole--drug of choice for trichinellosis--on the total activity and kinetics of cytosolic GST in the mouse intestines during experimental trichinellosis. Our results showed a statistically significant decrease in the total G...

BACKGROUND The glyoxalase system including two thiol-dependent enzymes, glyoxalase I (Glo-I) and glyoxalase II, plays an important role in a ubiquitous metabolic pathway involved in cellular detoxification of cytotoxic 2-oxoaldehydes. Tumor cells have high glycolytic activity, leading to increased cellular levels of these toxic metabolites. The increased activity of the detoxification system in...

Viral infections and antiviral responses have been linked to several metabolic diseases, including Reye's syndrome, which is aspirin-induced hepatotoxicity in the context of a viral infection. We identify an interferon regulatory factor 3 (IRF3)-dependent but type I interferon-independent pathway that strongly inhibits the expression of retinoid X receptor alpha (RXRalpha) and suppresses the in...

24 Abstract 25 26 We studied the metabolic costs associated with the ingestion of peppertree fruits (Schinus molle) in the culpeo fox, 27 Pseudalopex culpaeus, the second largest canid in South America. Throughout its range of distribution, this fox feeds 28 on rodents and other small vertebrates, and also on peppertree fruits, which represent 98% of total fruits consumed in 29 semiarid Chile. ...

Overnutrition is one of the major causes of non-alcoholic fatty liver disease (NAFLD). NAFLD is characterized by an accumulation of lipids (triglycerides) in hepatocytes and is often accompanied by high plasma levels of free fatty acids (FFA). In this study, we compared the energy metabolism in acute steatotic and non-steatotic primary mouse hepatocytes. Acute steatosis was induced by pre-incub...

Word liverderived from heparor hepatwhich is a Greek word, a lifeline, indeed, relentlessly round the clock involved in from metabolism to digestion via aiding emulsification of lipid, synthesis of plasma protein to glycogen storage & also synthesis of bile & hormones to detoxification, to keep us hale and hearty. But,at times due to multiple factors like infection, drug, ischaemic, alcohol, dr...

Organisms have metabolic pathways that are responsible for removing toxic agents. We always associate the liver as the major organ responsible for detoxification of the body; however this process occurs in many tissues. In the same way, as in the liver, the brain expresses metabolic pathways associated with the elimination of xenobiotics. Besides the detoxifying role of CYP2E1 for compounds suc...

Glutathione (GSH), a tripeptide (L γ-glutamyl-cysteinyl-glycine) is the major nonprotein thiol found abundantly in eukaryotic cells (1–3). GSH plays a critical role in many metabolic pathways. It acts as a cofactor for intracellular enzymes like the glutathione S-transferases (GST) and glutathione peroxidase; it aids in amino acid transport and is essential for detoxification of xenobiotics and...

Hepatopathy or hepatic insufficiency is a very common problem in dogs due to ingestion of some chemicals, drugs like paracetamol, furosemide etc., toxins and infectious agents. Since liver plays the very vital role for normal metabolic functions of carbohydrate, protein and fats, synthesis of plasma proteins, erythropoiesis and detoxification etc., hepatic dysfunctions leads in inappetence, wei...

Diabetes mellitus is the most common metabolic disease, and has late complications that are due to chronic hyperglycaemia. Altered carbohydrate and lipid metabolism together with impaired detoxification of carbonyl substrates and impaired trapping of oxygen radicals are responsible for cell damage in diabetes. Variable functional capacity of detoxifying systems could contribute to differing sus...