Quantitative synthesis of research results multiple small clinical trials using the statistical techniques of meta-analysis yields conclusions in excellent agreement with large randomized “mega-trails”. The present paper introduces a simple yet powerful method of meta-analysis for combining results of any published studies of a proposed treatment compared with a suitable control. These may incl...

Statistical synthesis of research findings via meta-analysis is widely used to assess the relative effectiveness of competing interventions. A series of three papers aimed at familiarising mental health scientists with the key statistical concepts and problems in meta-analysis was recently published in this journal. One paper focused on the selection and interpretation of the appropriate model ...

microwave irradiation is used in the synthesis of four tricyclic chromanones 11-14. the chromanone 14 and 12 are selectively formed thermally and under microwave in the presence of polyphosphoric acid (ppa) from the same dicarboxylic acid 9, respectively. the crystal structures of the two diacids are also reported. the corresponding ortho and meta isomers of diacids crystallize in the space gro...

OBJECTIVE To systematically review the qualitative literature of the lived experience of people with a chronic headache disorder. BACKGROUND Chronic headaches affect 3%-4% of the population. The most common chronic headache disorders are chronic migraine, chronic tension-type headache and medication overuse headache. We present a systematic review and meta-ethnographic synthesis of the lived ...

This paper is to about the main contents and basic working principles of information system meta-synthesis based on SOA. In the anterior part of the paper, we explained the current situations of the information system management and working conditions, and pointed out the reasons why we had to think over the disadvantages and advantages of information system meta-synthesis. In the middle part o...

BACKGROUND Network meta-analysis methods extend the standard pair-wise framework to allow simultaneous comparison of multiple interventions in a single statistical model. Despite published work on network meta-analysis mainly focussing on the synthesis of aggregate data, methods have been developed that allow the use of individual patient-level data specifically when outcomes are dichotomous or...

This checklist is for the review of evidence syntheses for treatment efficacy used in decision making based on either efficacy or cost-effectiveness. It is intended to be used for pairwise meta-analysis, indirect comparisons, and network meta-analysis, without distinction. It does not generate a quality rating and is not prescriptive. Instead, it focuses on a series of questions aimed at reveal...

We set out a generalized linear model framework for the synthesis of data from randomized controlled trials. A common model is described, taking the form of a linear regression for both fixed and random effects synthesis, which can be implemented with normal, binomial, Poisson, and multinomial data. The familiar logistic model for meta-analysis with binomial data is a generalized linear model w...