BACKGROUND The induction of heat shock protein (HSP) 72 by mild electrical stimulation with heat shock (MES + HS), which improves visceral adiposity and insulin resistance in mice, may be beneficial in treating metabolic syndrome (MS) or type 2 diabetes mellitus (T2DM). METHODS Using open-label crossover trials, 40 subjects with MS or T2DM were randomly assigned using computer-generated rando...

The paper is focused mainly on ERP and MES integration and is structured in the following way. Firstly the background on ERP and MES Evolution is presented. Then, MES functionalities are analyzed and a modified functionality model is suggested. After that a pertinent issues of ERP and MES are treated. In the final section will be discussed decisive findings and future trends of MESs, which are ...

A new tripodal ligand that features three selenium donors, namely the tris(2-seleno-1-mesitylimidazolyl)hydroborato ligand, [Tse(Mes)], has been constructed via the reaction of KBH(4) with 1-mesitylimidazole-2-selone; comparison of the IR spectroscopic data of [Tse(Mes)]Re(CO)(3) with those of a variety of related LRe(CO)(3) complexes demonstrates that the [Tse(Mes)] ligand is more strongly ele...

The germline of the nematode Caenorhabditis elegans exhibits a remarkable ability to specifically silence transgenic DNA. We have shown that this silencing mechanism is disrupted in animals mutant for the maternal effect sterile genes mes-2, mes-3, mes-4 and mes-6. The proteins encoded by mes-2 and mes-6 have been shown to be related to the Polycomb Group of transcriptional repressors (Holdeman...

Integrated manufacturing systems have always found in the hardware and software heterogeneity among different vendors an obstacle to their satisfactory implementation. Nowadays, new Open and Distributed Systems technologies have appeared, providing a new integration potential, accelerating the implementation of MES (Manufacturing Execution Systems) and making it’s integration to other corporate...

BACKGROUND Metabolic syndrome (MeS) is being recognized as a risk factor for insulin resistance and cardiovascular disease. The present study was aimed to find out the possible association between 45-bp I/D polymorphism of uncoupling protein 2 (UCP2) and MeS. METHODS DNA was extracted from peripheral blood of 151 subjects with and 149 subjects without MeS. 45-bp I/D variant of UCP2 was detect...

A series of 5-carbomethoxybenzoxazole derivatives (6a-t) were prepared by using methyl-p-hydroxybenzoate. The identity of the compounds was confirmed on the basis of their elemental analysis and spectral data. In anti-MES test compounds 6b, 6d, 6h, 6j, 6m, 6p, 6q and 6s showed potent activity parallel to lipophilicity. Compounds 6b, 6d, 6k, 6n and 6s successfully passed the rotorod test without...

We report here genome-wide mapping of DNA methylation patterns at proximal promoter regions in mouse embryonic stem (mES) cells. Most methylated genes are differentiation associated and repressed in mES cells. By contrast, the unmethylated gene set includes many housekeeping and pluripotency genes. By crossreferencing methylation patterns to genome-wide mapping of histone H3 lysine (K) 4/27 tri...

OBJECTIVE To investigate the association between carotid plaque characteristics and the occurrence of cerebral microemboli signals (MES) and subsequent ischemic events in patients with asymptomatic carotid stenosis (ACS). DESIGN Sixty-two asymptomatic patients with 50-99% carotid stenosis underwent transcranial Doppler (TCD) monitoring to determine the relationship between MES and plaque char...

Metabolic syndrome (MeS), a cluster of several metabolic disorders, is increasingly being recognized as a risk factor for type II diabetes (T2D) and cardiovascular disease. Genetic and epigenetic alteration of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) has been associated with components of MeS. The aim of the present study was to investigate the possible association of...