نتایج جستجو برای: menstrual cyc
تعداد نتایج: 13985 فیلتر نتایج به سال:
Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constant as low as the nanomolar level. However, there have been no reports on the stereochemistry of th...
Ontologies are commonly used for annotating textual data mainly based on human language technologies [1]. This research focuses on manual extensions of ontologies to support the annotation of business news. Experiments were conducted on a well known Cyc ontology and using Cyc annotator on two business news datasets. We show that the proposed extensions of ontology results in annotation with bet...
We associate a graph CG to a non locally cyclic group G (called the non-cyclic graph of G) as follows: take G\Cyc(G) as vertex set, where Cyc(G) = {x ∈ G | 〈x, y〉 is cyclic for all y ∈ G} is called the cyclicizer of G, and join two vertices if they do not generate a cyclic subgroup. For a simple graph Γ, w(Γ) denotes the clique number of Γ, which is the maximum size (if it exists) of a complete...
Cycorp has developed a knowledge acquisition system, based on Cyc, that can engage a user in a natural-language mixed-initiative dialogue. In order to achieve a intelligent dialogue with the user, it employs explicit topicand user-modeling, a system of prioritized interactions, and a transparent agenda to which either the user or the system can add interactions at any time. Interactions initiat...
Two unrelated patients with a congenital bleeding diathesis associated with a severe defect of the platelet ADP receptor coupled to adenylate cyclase (P2(CYC)) have been described so far. In one of them, platelet secretion was shown to be abnormal. We recently showed that platelets with the primary secretion defect (PSD; characterized by abnormal secretion but normal granule stores, thromboxane...
Wegener granulomatosis (WG), the most common of the pulmonary granulomatous vasculitides, typically involves the upper respiratory tract, lower respiratory tract (bronchi and lung), and kidney, with varying degrees of disseminated vasculitis. THE TERM GRANULOMATOSIS WITH POLYANGIITIS (WEGENER) WAS RECENTLY PROPOSED TO REPLACE THE OLDER TERM, WG. THE TERM GRANULOMATOSIS WITH POLYANGIITIS CAN BE ...
Kaposi's sarcoma-associated herpesvirus (KSHV or human herpesvirus 8) is a novel gammaherpesvirus implicated in the cause of Kaposi's sarcoma and certain malignancies of lymphatic origin. One of the candidate genes possibly involved in promoting tumor development is an open reading frame (ORF) with sequence similarity to human type D cyclin genes. This cyclin-like gene, when expressed in tissue...
OBJECTIVE Scleroderma-related interstitial lung disease (SSc-ILD) has limited therapeutic options due to unclear pathogenesis. Recently, PDGF receptor (PDGFR) amplification has been postulated to cause fibrosis. We hypothesized that a combination of immunosuppressive agents, e.g. cyclophosphamide (CYC) and imatinib (PDGFR inhibitor), might be useful for treating SSc-related ILD. Our objective w...
This paper assessed the burden of adverse events (AEs) associated with azathioprine (AZA), cyclophosphamide (CYC), mycophenolate mofetil (MMF), methotrexate (MTX), and cyclosporine (CsA) in patients with systemic lupus erythematosus (SLE). Thirty-eight publications were included. Incidence of AEs ranged from 42.8% to 97.3%. Common AEs included infections (2.4-77%), gastrointestinal AEs (3.2-66....
OBJECTIVE To investigate association between genetic polymorphisms of GST, CYP and renal outcome or occurrence of adverse drug reactions (ADRs) in lupus nephritis (LN) treated with cyclophosphamide (CYC). CYC, as a pro-drug, requires bioactivation through multiple hepatic cytochrome P450s and glutathione S transferases (GST). METHODS We carried out a multicentric retrospective study including...
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