BACKGROUND The endothelial function has been proven to be an important factor in the pathogenesis of atherosclerosis, hypertension and heart failure. The flow-mediated vasodilation (FMD) of the peripheral artery is an endothelium-dependent function. Brachial-artery ultrasound scanning is the popular method for evaluating FMD. However, good technical training on ultrasonography is required for t...

Menstruation-associated disorders negatively interfere with the quality of life of many women. However, mechanisms underlying pathogenesis of menstrual disorders remain poorly investigated up to date. Among others, this is based on a lack of appropriate pre-clinical animal models. We here employ a mouse menstruation model induced by priming mice with gonadal hormones and application of a physic...

Endogenous female sex hormones influence muscle sympathetic nerve activity (MSNA), a regulator of arterial blood pressure and important factor in hypertension development. Although ≈80% of American women report using hormonal contraceptives sometime during their life, the influence of combined oral contraceptives (OCs) on MSNA and systemic hemodynamics remains equivocal. The goal of this study ...

We evaluated the effects of the menstrual cycle and physical training on heat loss (sweating and cutaneous vasodilation) responses during moderate exercise in a temperate environment. Ten untrained (group U) and seven endurance-trained (group T) women (maximal O2 uptake of 36.7+/-1.1 vs. 49.4+/-1.7 ml.kg-1.min-1, respectively; P<0.05) performed a cycling exercise at 50% maximal O2 uptake for 30...

BACKGROUND Radiofrequency endometrial ablation (REA) is currently a second line treatment in women with heavy menstrual bleeding (MHB) if medical therapy (MTP) is contraindicated or unsatisfactory. Our objective is to compare the effectiveness and cost burden of MTP and REA in the initial treatment of HMB. METHODS We performed a randomized trial at Mayo Clinic Rochester, Minnesota. The planne...

Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in females of reproductive age group. It characterised by menstrual irregularities, enlarged ovaries, infertility, high levels male hormones, excess hair on face and body, acne obesity. PCOS can result from abnormal function hypothalamic-pituitary-ovarian axis. Women with have an increased risk diabetes, bloo...

OBJECTIVE Menstrual disorders are common in young women, and heavy menstrual blood losses (MBL) are an important cause of anaemia. Menstrual morbidity normally goes untreated in developing countries where cultural barriers also serve to mask the problems. We investigated the prevalence of menstrual morbidity, and measured MBL and its relationship to iron deficiency in a rural adolescent populat...

background: heavy menstrual bleeding of endometrial origin (hmb) is a major healthcare problem in premenopausal women and affects several aspects of women’s health and quality of life (qol). the aim of this study was to compare the efficacy of persian golnar (pg) and tranexamic acid (ta) on heavy menstrual bleeding of endometrial origin (hmb) and patients’ qol. methods : a double-blind randomiz...

There is a need for long-acting birth control methods. Copper-bearing intrauterine contraceptive devices do not have systemic side effects and they are appropriate for parous women who have no excess menstrual flow or cramps at baseline and who have low risk for sexually transmitted infections. Levonorgestrel-releasing intrauterine systems release levonorgestrel directly into uterine cavity. Th...

The aim of the present study was to assess predictive factors for occurrence of idiopathic menorrhagia (IM), a disease characterized by abnormal endometrial blood vessel morphology. It was hypothesized that IM exhibits familial clustering (suggesting inheritance) and is associated with other vascular abnormalities, primarily cutaneous hemangiomas. Women with IM (n=152) and healthy, regularly me...