OBJECTIVE To discuss the application of ARMS method to detect EGFR gene mutation in cerebrospinal fluid of lung adenocarcinoma patients with meningeal metastasis. METHODS 5 cases of lung adenocarcinoma were identified with meningeal metastasis that were cleared EGFR gene mutation by gene sequencing method. From each patient 5ml cerebrospinal fluid was obtained by lumbar puncture. ARMS method ...

Plasma cell granuloma (PCG) are uncommon non-neoplastic masses of unknown etiology, characterized histologically by proliferation of connective tissue with an inflammatory infiltrate of mononuclear elements. They occur more commonly in the lung and conducting airways, but can also be seen in other tissues, such as the meninges. The imaging appearance of meningeal PCG can simulate more common ne...

The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development. Through the release of diffusible factors, the meninges influence the proliferative and migratory behaviors of neural progenitors and neurons in the forebrain and ...

An anatomical-angiographic classification for carotid-cavernous sinus fistulas is introduced and a series of 14 patients with spontaneous carotid-cavernous sinus fistulas is reviewed to illustrate the usefulness of such a classification for patient evaluation and treatment. Fistulas are divided into four types: Type A are direct high-flow shunts between the internal carotid artery and the caver...

Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a pe...

Infectious meningeal syndromes represent a serious medical emergency whose clinical-epidemiologic diagnosis must be immediately established for early initiation of appropriate treatment. However, in many cases data from the clinical exam are insufficient to confirm or rule out the diagnosis. Therefore, the aim of this work was to assess the value of the ocular globe compression sign in 57 patie...

Two cases of meningeal invasion by non-myelomatous plasma cell dyscrasias--a plasma cell leukaemia and an extramedullary plasmacytoma--are described. Both were secretors of IgD paraprotein and both were diagnosed in life, characteristics which we have not found in any other published case of plasma cell leptomeningitis. Analysis of our patients and of another 25 cases suggests as predisposing f...

This is a report on 2 cases of plaguemeningitis observed by us among the comparatively small material of 41 instances of plague treated at Wellington, Nilgiris, in 1945-46. We consider our cases worthy of record as the cerebro-spinal type of plague has been described in very few instances only, the disease being believed to be of extreme rarity. Lewillon, Devignat and Schoetter (1940) reported ...

Aims. We report on the unusual case of a 43-year-old man who developed recurrent meningeal hemangiopericytoma and presented with hypoglycemia 6 years after excision of the tumor. Methods and Results. We utilized computed tomography to assure multiple tumor metastasis and cranial recurrence of previous meningeal hemangiopericytoma and clinical laboratory tests and immunohistochemical staining to...

Extradural meningeal cysts are rare lesions and are uncommon causes of spinal cord or nerve compression. Most of these lesions probably remain unrecognized life-long, because they cause no symptoms. With the widespread use of new imaging techniques, asymptomatic spinal extradural meningeal cysts are becoming increasingly common. The therapeutic guidelines have not been well-established yet. Gen...