OBJECTIVE Determine the outcome of hearing in Meniere's Disease (MD) after antiviral treatment. STUDY DESIGN Prospective study. SETTING University Hospital. METHODS Thirty one new patients with a diagnosis of MD were treated with antiviral drugs during 2012. Acyclovir or valacyclovir was used depending on insurance coverage and cost. A standard dose of 800 mg (acyclovir) or 1g (valacyclov...

This paper analyzes how an inventor should …x the licensing terms to license a standard in complying with a non-discrimination requirement. Using a model incorporating imperfect competition between a …nite number of users and product di¤erentiation, we compare three di¤erent regimes: …xed fee (also known as royalty free), per unit royalty and two-part tari¤. We highlight the di¤erent e¤ects of ...

Ménière's disease (MD) is a complex, multifactorial disorder of the inner ear that is the most common cause of the syndrome of episodic vertigo combined with fluctuating hearing loss. In spite of a century of investigation, the etiology and pathophysiology of MD remain controversial and incompletely understood. Among the factors that have contributed to these controversies are the absence of (1...

This study assesses several electrocochleographic (ECoG) duration and amplitude measures in a clinically defined Meniere's group and compares the results with those from a normal hearing control group and a hearing loss group (cochlear). The summating potential (SP)/action potential (AP) amplitude ratio was the most efficient diagnostic measure, with 62% of the Meniere's group demonstrating abn...

It is likely that as new approaches are introduced in the treatment of any condition which hitherto has seemed intractable the value of the older methods may be forgotten. Thi8 is especially true when the new approaches are introduced by members of another specialty. Such in this country appears to be the fate of vestibular neurotomy in the treatment of Miniere's disease, particularly in those ...

OBJECTIVE To evaluate the effectiveness of transtympanic gentamicin treatment in Meniere's disease. MATERIAL AND METHOD The present study is a prospective study of 8 patients in Ramathibodi Hospital who had transtympanic gentamicin treatment of Meniere's disease by fixed dose regimen of 12 injections during a period of 4 days. The committee on hearing and equilibrium guidelines for reporting ...

BACKGROUND Existing scales of self-perceived disablement in patients with vestibular impairment either are too broad to detect the subtle deficits in this population or omit some important daily life tasks. OBJECTIVES To develop a scale to assess self-perceived disablement in patients with vestibular impairment and to describe the development and initial testing of this new assessment tool. ...

Electrocochleography (ECochG) has evolved as an important tool in the diagnosis/assessment/monitoring of Ménière's disease/endolymphatic hydrops (MD/ELH). This manuscript provides an update on the use of ECochG for these purposes. The material presented includes descriptions of the components of the electrocochleogram; ECochG recording approaches and parameters; how to prepare for an exam, incl...

Different balance problems may occur in the same patient simultaneously, and the other problem may be overlooked if the clinician does not pay much attention. Spontaneous nystagmus of Meniere's disease and positional nystagmus of posterior canal BPPV in the same patient is presented. Positional tests must always be considered even in the presence of spontaneous nystagmus.

Transtympanic gentamicin administration has become a popular modality in the treatment of Ménière's disease. This modality and other inner-ear medical therapy are gaining increased clinical and scientific attention. We previously described the kinetics and effects of gentamicin uptake into the inner ear after delivery of the medicine into the middle ear using a variety of different techniques a...