Phenotype-guided re-profiling of approved drug molecules presents an accelerated route to developing anticancer therapeutics by bypassing the target-identification bottleneck of target-based approaches and by sampling drugs already in the clinic. Further, combinations incorporating targeted therapies can be screened for both efficacy and toxicity. Previously we have developed an oncogenic-RAS-d...

The normal products of the murine Steel (Sl) and Dominant white spotting (W) genes are essential for the development of melanocyte precursors, germ cells, and hematopoietic cells. The Sl locus encodes stem cell factor (SCF), which is the ligand of c-kit, a receptor tyrosine kinase encoded by the W locus. One allele of the Sl mutation, Sl17H, exhibits minor hematopoietic defects, sterility only ...

Abstract Introduction: Pigmented odontogenic lesions are rare; to date, only 60 cases have been reported in the literature. Melanocytes have been detected in a wide variety of odontogenic lesions. Several studies have discussed melanocyte presence and melanin production in odontogenic lesions, but its origin is still unclear. Therefore, the present systematic review aimed to gather information...