I read with interest the report by Brisson and Brisson that showed higher compliance among U.S. military service members in Afghanistan with daily as compared with weekly malaria chemoprophylaxis. By conventional wisdom these results appear counterintuitive, and they stand in contrast to earlier findings among civilian travelers and military personnel that suggest observed compliance should be ...

Erratum After publication of the original article [1], it came to the authors’ attention that there was an error in the PQ pharmacokinetics sub-section of the Background section. The following sentence is affected: “There is no PK interaction between PQ and either artesunate-pyronaridine [76] or mefloquine [69, 77]; no PK interaction data exist for PQ and artemetherlumefantrine (AL).” This sent...

A total of 141 cases of strictly defined cerebral malaria were studied in a controlled trial of three regimens: (1) intramuscular artemether plus oral mefloquine, (2) intravenous artesunate plus oral mefloquine, and (3) intravenous quinine (with or without an initial loading dose) plus oral tetracycline. The overall mortalities in each group were 14%, 8.3% and 34.3% respectively. The average pa...

BACKGROUND The World Health Organization (WHO) is promoting artemether-lumefantrine for treating uncomplicated malaria. The objective of this review is to summarize available evidence of its effects compared with other antimalarial regimens. METHODS We sought randomized and quasi-randomized studies comparing artemether-lumefantrine with any other antimalarial drug regimen. Databases searched ...